NDLI: The Evolution and Treatment of Korsakoff's Syndrome

Please wait, while we are loading the content...

The Evolution and Treatment of Korsakoff's Syndrome

Content Provider	PubMed Central
Author	Thomson, A. D. Guerrini, Irene Marshall, E. Jane
Abstract	Wernicke’s Encephalopathy is an acute neuro-psychiatric condition caused by an insufficient supply of thiamine (Vitamin B1) to the brain. If undiagnosed or inadequately treated, it is likely to proceed to Korsakoff’s Syndrome. Wernicke’s Encephalopathy can result from dietary deficiency alone and this form is usually successfully treated, with little chance of Korsakoff’s Syndrome supervening. On the other hand, thiamine deficiency associated with alcohol misuse/dependence may require up to 1 gram of thiamine IV in the first 24 hours to be treated successfully. The reasons for this difference in treatment will be discussed. Thiamine diphosphate acts as a co-factor for a number of thiamine-dependent enzymes. Thiamine deficiency leads to a reduction in the activity of these enzymes, and this leads to alterations in mitochondrial activity, impairment of oxidative metabolism, decreased energy status and eventually selective neuronal death. The damage caused by the combination of thiamine deficiency and alcohol metabolism probably interferes with adequate thiamine transport at a number of sites in the body, including the blood–brain barrier, as well as causing damage to the apoenzymes which then require higher concentrations of thiamine to work normally. The accumulated damage is likely to render the use of oral thiamine therapeutically inadequate since the body is unable to produce high enough concentrations of thiamine in the blood to traverse the blood–brain barrier. Some individuals are probably genetically predisposed to develop Wernicke’s. Long before individuals with alcohol misuse or dependence develop Wernicke’s Encephalopathy the neurons and other cells of the body are functioning sub-optimally because of the inadequate supply of thiamine and the neurotoxic effect of alcohol. This relative deficiency initiates a series of pathological changes which accumulate and further interfere with the supply of thiamine and its utilisation at a time when the requirements are increased. The best treatment for Korsakoff’s Syndrome is timely recognition of Wernicke’s Encephalopathy and appropriate intervention and prevention.
Related Links	http://dx.doi.org/10.1007/s11065-012-9196-z
Starting Page	81
File Format	PDF
ISSN	15736660
e-ISSN	15736660
Journal	Neuropsychology Review
Issue Number	2
Volume Number	22
Language	English
Publisher	Springer US
Publisher Date	2012-06-01
Access Restriction	Open
Rights Holder	Springer US
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuropsychology and Physiological Psychology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Evolution and Treatment of Korsakoff's Syndrome

Neuroimaging of Wernicke's Encephalopathy and Korsakoff's Syndrome

Wernicke's Encephalopathy and Korsakoff's Syndrome Revisited

The Evolution and Treatment of Korsakoff's Syndrome : Out of Sight, Out of Mind?

Confabulation or delusion?: A case of schizophrenia and alcohol dementia masquerading as Korsakoff's syndrome

The image of memory: relationship between autobiographical memory and mental imagery in Korsakoff syndrome

Context Memory in Korsakoff’s Syndrome

Numerosity Impairment in Corticobasal Syndrome

Anterograde Episodic Memory in Korsakoff Syndrome

The Evolution and Treatment of Korsakoff's Syndrome

Similar Documents

The Evolution and Treatment of Korsakoff's Syndrome

Neuroimaging of Wernicke's Encephalopathy and Korsakoff's Syndrome

Wernicke's Encephalopathy and Korsakoff's Syndrome Revisited

The Evolution and Treatment of Korsakoff's Syndrome : Out of Sight, Out of Mind?

Confabulation or delusion?: A case of schizophrenia and alcohol dementia masquerading as Korsakoff's syndrome

The image of memory: relationship between autobiographical memory and mental imagery in Korsakoff syndrome

Context Memory in Korsakoff’s Syndrome

Numerosity Impairment in Corticobasal Syndrome

Anterograde Episodic Memory in Korsakoff Syndrome

The Evolution and Treatment of Korsakoff's Syndrome