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| Content Provider | PubMed Central |
|---|---|
| Author | Mahdi, Behdani Zeinali, Sirous Karimipour, Morteza Hossein, Khanahmad Nader, Asadzadeh Kayhan, Azadmanesh Seyed, Negar Baniahmad, Seyed Farzad Habibi, Anbouhi Mahdi |
| Copyright Year | 2012 |
| Abstract | Antibodies and their derivative fragments have long been used as tools in a variety of applications, in fundamental research work, biotechnology, diagnosis, and therapy. Camels produce single heavy-chain antibodies (VHH) in addition to usual antibodies. These minimal-sized binders are very robust and bind the antigen with high affinity in a monomeric state. Vascular endothelial growth factor recepror-2 (VEGFR2) is an important tumor-associated receptor that blockade of its signaling can lead to the inhibition of neovascularization and tumor metastasis. Here, we describe the construction, expression, and purification VEGFR2-specific Diabody. Two variable fragments of a same camel anti-VEGFR2 antibody were linked together by the upper hinge segment of antibody to make a diabody. We showed the ability of diabody to recognition of VEGFR2 on the cell surface by FACS. Diabodies can be produced in the low-cost prokaryotic expression system, so they are suitable molecules for diagnostic and therapeutic issues. |
| Related Links | http://dx.doi.org/10.4103/2277-9175.100126 |
| Starting Page | 34 |
| File Format | |
| ISSN | 22779175 |
| e-ISSN | 22779175 |
| Journal | Advanced Biomedical Research |
| Volume Number | 1 |
| Language | English |
| Publisher | Medknow Publications & Media Pvt Ltd |
| Publisher Date | 2012-08-28 |
| Access Restriction | Open |
| Rights Holder | Medknow Publications & Media Pvt Ltd |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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