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| Content Provider | PubMed Central |
|---|---|
| Author | Miyazaki, Yukihiro Nawa, Yuichiro Miyagawa, Masao Kohashi, Sumiko Nakase, Koichi Yasukawa, Masaki Hara, Masamichi |
| Abstract | The treatment of patients with diffuse large B cell lymphoma (DLBCL) would be greatly facilitated with a rapid method for determining prognosis that can be performed more easily and earlier than cytological or specific pathological examinations. It has been suggested that newly diagnosed patients with DLBCL who have low maximum standard uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) are more likely to be successfully treated and remain in remission compared with patients with high SUVmax, but this concept has been poorly studied. We retrospectively analyzed 50 patients with de novo DLBCL to evaluate the relationship between the SUVmax and disease progression. For patients with low SUVmax (n = 10) and high SUVmax (n = 40) (P = 0.255), respectively, the 3-year overall survival rates were 90 and 72 %, and the progression-free survival (PFS) rates were 90 and 39 % (P = 0.012). By multivariate analysis, the revised International Prognostics Index (R-IPI) and SUVmax at diagnosis were shown to predict longer PFS. The 3-year PFS for patients with low SUVmax classified into the good prognosis group by R-IPI was 100 vs. 62 % for those with high SUVmax (P = 0.161), and patients with low SUVmax classified into the poor prognosis group by R-IPI was 80 vs. 18 % for those with high SUVmax (P = 0.050). We conclude that the SUVmax on FDG-PET for newly diagnosed patients with DLBCL is an important predictor of disease progression, especially for patients with poor prognosis by R-IPI. |
| Related Links | http://dx.doi.org/10.1007/s00277-012-1602-3 |
| Ending Page | 244 |
| Page Count | 6 |
| Starting Page | 239 |
| File Format | |
| ISSN | 09395555 |
| e-ISSN | 14320584 |
| Journal | Annals of Hematology |
| Issue Number | 2 |
| Volume Number | 92 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2013-02-01 |
| Access Restriction | Open |
| Rights Holder | Springer-Verlag |
| Subject Keyword | Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
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