NDLI: Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia

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Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia

Content Provider	PubMed Central
Author	Cote, C. K. Kaatz, L. Reinhardt, J. Bozue, J. Tobery, S. A. Bassett, A. D. Sanz, P. Darnell, S. C. Alem, F. O’brien, A. D. Welkos, S. L.
Abstract	Current vaccine approaches to combat anthrax are effective; however, they target only a single protein [the protective antigen (PA) toxin component] that is produced after spore germination. PA production is subsequently increased during later vegetative cell proliferation. Accordingly, several aspects of the vaccine strategy could be improved. The inclusion of spore-specific antigens with PA could potentially induce protection to initial stages of the disease. Moreover, adding other epitopes to the current vaccine strategy will decrease the likelihood of encountering a strain of Bacillus anthracis (emerging or engineered) that is refractory to the vaccine. Adding recombinant spore-surface antigens (e.g. BclA, ExsFA/BxpB and p5303) to PA has been shown to augment protection afforded by the latter using a challenge model employing immunosuppressed mice challenged with spores derived from the attenuated Sterne strain of B. anthracis. This report demonstrated similar augmentation utilizing guinea pigs or mice challenged with spores of the fully virulent Ames strain or a non-toxigenic but encapsulated ΔAmes strain of B. anthracis, respectively. Additionally, it was shown that immune interference did not occur if optimal amounts of antigen were administered. By administering the toxin and spore-based immunogens simultaneously, a significant adjuvant effect was also observed in some cases. Thus, these data further support the inclusion of recombinant spore antigens in next-generation anthrax vaccine strategies.
Related Links	http://dx.doi.org/10.1099/jmm.0.045393-0
Ending Page	1392
Page Count	13
Starting Page	1380
File Format	PDF
ISSN	00222615
e-ISSN	14735644
Journal	Journal of Medical Microbiology
Issue Number	Pt 10
Volume Number	61
Language	English
Publisher	Society for General Microbiology
Publisher Date	2012-10-01
Access Restriction	Open
Rights Holder	Society for General Microbiology
Subject Keyword	Microbiology (medical) Microbiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Microbiology Microbiology (medical)

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