NDLI: Transcriptional modulation of the developing immune system by early life social adversity

Content Provider	PubMed Central
Author	Cole, Steven W. Conti, Gabriella Arevalo, Jesusa M. G. Ruggiero, Angela M. Heckman, James J. Suomi, Stephen J.
Abstract	To identify molecular mechanisms by which early life social conditions might influence adult risk of disease in rhesus macaques (Macaca mulatta), we analyze changes in basal leukocyte gene expression profiles in 4-mo-old animals reared under adverse social conditions. Compared with the basal condition of maternal rearing (MR), leukocytes from peer-reared (PR) animals and PR animals provided with an inanimate surrogate mother (surrogate/peer reared, SPR) show enhanced expression of genes involved in inflammation, cytokine signaling, and T-lymphocyte activation, and suppression of genes involved in several innate antimicrobial defenses including type I interferon (IFN) antiviral responses. Promoter-based bioinformatic analyses implicate increased activity of CREB and NF-κB transcription factors and decreased activity of IFN response factors (IRFs) in structuring the observed differences in gene expression. Transcript origin analyses identify monocytes and CD4+ T lymphocytes as primary cellular mediators of transcriptional up-regulation and B lymphocytes as major sources of down-regulated genes. These findings show that adverse social conditions can become embedded within the basal transcriptome of primate immune cells within the first 4 mo of life, and they implicate sympathetic nervous system-linked transcription control pathways as candidate mediators of those effects and potential targets for health-protective intervention.
Related Links	http://dx.doi.org/10.1073/pnas.1218253109
Ending Page	20583
Page Count	6
Starting Page	20578
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	50
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-12-11
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Transcriptional modulation of the developing immune system by early life social adversity

Transcriptional modulation of the developing immune system by early life social adversity.

Primate evidence on the late health effects of early-life adversity

Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction

Associations between early life adversity and executive function in children adopted internationally from orphanages

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics

DNA methylation of BDNF as a biomarker of early-life adversity

Early-Life Adversity Leaves Its Imprint on the Oral Microbiome for More Than 20 Years and Is Associated with Long-Term Immune Changes

Transcriptional modulation of the developing immune system by early life social adversity

Similar Documents

Transcriptional modulation of the developing immune system by early life social adversity

Transcriptional modulation of the developing immune system by early life social adversity.

Primate evidence on the late health effects of early-life adversity

Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction

Associations between early life adversity and executive function in children adopted internationally from orphanages

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics

DNA methylation of BDNF as a biomarker of early-life adversity

Early-Life Adversity Leaves Its Imprint on the Oral Microbiome for More Than 20 Years and Is Associated with Long-Term Immune Changes

Transcriptional modulation of the developing immune system by early life social adversity