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| Content Provider | PubMed Central |
|---|---|
| Author | Carreira, José Muñoz, Emilio |
| Abstract | The action of atebrin on purified adenosine triphosphatase (ATPase) from Micrococcus lysodeikticus was studied as well as on the membrane-bound and soluble ATPases from Escherichia coli and Bacillus megaterium. Atebrin inhibited the Ca2+-dependent activity of all these enzymes, and the inhibition was reversed by an excess of Ca2+ ions. Kinetic studies carried out with the purified enzyme from M. lysodeikticus showed that the inhibition by atebrin was strongly cooperative, suggesting the complex nature of the process. On the other hand, atebrin stimulated the Mg2+ATPase activity of the M. lysodeikticus enzyme, displacing its adenosine 5′-triphosphate (ATP)/Mg2+ optimum ratios, but inhibited the Mg2+-ATPase activity of E. coli provided that ATP was in excess over Mg2+, i.e., that the ATP/Mg2+ ratio was higher than its optimum. These results suggest that divalent cations influence the bacterial ATPases in different ways depending on the type of divalent ion and/or enzyme. The effect of atebrin on bacterial ATPases may reflect those differences, and its complex mechanism of action might be related to the existence of more than one site for divalent cations and/or distinct conformational states in these enzymes. |
| Starting Page | 38 |
| File Format | |
| ISSN | 10986596 |
| e-ISSN | 10986596 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher Date | 1977-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) |
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