NDLI: White-Matter Diffusion fMRI of Mouse Optic Nerve

Content Provider	PubMed Central
Author	Spees, William M. Lin, Tsen-hsuan Song, Sheng-kwei
Copyright Year	2012
Abstract	Non-invasive assessment of white-matter functionality in the nervous system would be a valuable basic neuroscience and clinical diagnostic tool. Using standard MRI techniques, a visual-stimulus-induced 27% decrease in the apparent diffusion coefficient of water perpendicular to the axonal fibers (ADC⊥) is demonstrated for C57BL/6 mouse optic nerve in vivo. No change in ADC\|\| (diffusion parallel to the optic nerve fibers) was observed during visual stimulation. The stimulus-induced changes are completely reversible. A possible vascular contribution was sought by carrying out the ADC⊥ measurements in hypercapnic mice with and without visual stimulus. Similar effects were seen in room-air-breathing and hypercapnic animals. The in vivo stimulus-induced ADC⊥ decreases are roughly similar to literature reports for ex vivo rat optic nerve preparations under conditions of osmotic swelling. The experimental results strongly suggest that osmotic after-effects of nerve impulses through the axonal fibers are responsible for the observed ADC decrease.
Related Links	http://dx.doi.org/10.1016/j.neuroimage.2012.10.021
Ending Page	215
Page Count	7
Starting Page	209
File Format	PDF
ISSN	10959572
e-ISSN	10959572
Journal	NeuroImage
Volume Number	65
Language	English
Publisher Date	2013-01-15
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Cognitive Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis

Local White Matter Geometry from Diffusion Tensor Gradients

Quantitative Tractography Metrics of White Matter Integrity in Diffusion-Tensor MRI

A Computational Model for Diffusion Weighted Imaging of Myelinated White Matter

Direct Segmentation of the Major White Matter Tracts in Diffusion Tensor Images

Stereotaxic White Matter Atlas Based on Diffusion Tensor Imaging in an ICBM Template

The relationship between diffusion tensor imaging and volumetry as measures of white matter properties

Auditory tracts identified with combined fMRI and diffusion tractography

Functional changes of apparent diffusion coefficient during visual stimulation investigated by diffusion-weighted gradient-echo fMRI

White-Matter Diffusion fMRI of Mouse Optic Nerve

Similar Documents

Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis

Local White Matter Geometry from Diffusion Tensor Gradients

Quantitative Tractography Metrics of White Matter Integrity in Diffusion-Tensor MRI

A Computational Model for Diffusion Weighted Imaging of Myelinated White Matter

Direct Segmentation of the Major White Matter Tracts in Diffusion Tensor Images

Stereotaxic White Matter Atlas Based on Diffusion Tensor Imaging in an ICBM Template

The relationship between diffusion tensor imaging and volumetry as measures of white matter properties

Auditory tracts identified with combined fMRI and diffusion tractography

Functional changes of apparent diffusion coefficient during visual stimulation investigated by diffusion-weighted gradient-echo fMRI

White-Matter Diffusion fMRI of Mouse Optic Nerve