NDLI: Organelle size equalization by a constitutive process

Content Provider	PubMed Central
Author	Ludington, W. B. Shi, L. Z. Zhu, Q. Berns, M. W. Marshall, W. F.
Copyright Year	2012
Abstract	The spatial organization of a cell arises in part from the precise control of organelle size, but how a cell achieves this control remains an elusive problem. Two predominant models for size control persist, (i) induced control, where organelle genesis, maintenance, and disassembly are three separate programs that are activated in response to size change [1, 2], and (ii) constitutive control, where stable size results from the balance between continuous organelle assembly and disassembly [3, 4]. The problem has been studied for over 50 years in the bifllagellate Chlamydomonas reinhardtii because the flagella are easy to measure, their size changes only in the length dimension, and the genetics are comparable to yeast [5]. Length dynamics in Chlamydomonas flagella are quite robust: they maintain a length of about 12 µm and recover from amputation in about 90 min with a growth rate that decreases smoothly to zero as the length approaches 12 µm [6]. Despite a wealth of experimental studies, existing data are consistent with both induced and constitutive control models for flagella. Here we developed novel microfluidic trapping and laser microsurgery techniques in Chlamydomonas that allow us to distinguish between length control models by measuring the two flagella on a single cell as they equilibrate after amputation of a single flagellum. The results suggest that cells manage ciliary/flagellar length by constitutive control with a single, tunable cytoplasmic pool parameter.
Related Links	http://dx.doi.org/10.1016/j.cub.2012.09.040
Ending Page	2179
Page Count	7
Starting Page	2173
File Format	PDF
ISSN	09609822
e-ISSN	18790445
Journal	Current biology : CB
Issue Number	22
Volume Number	22
Language	English
Publisher Date	2012-11-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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