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| Content Provider | PubMed Central |
|---|---|
| Author | Taro, Hitosugi Zhou, Lu Shannon, Elf Fan, Jun Kang, Hee-bum Seo, Jae Ho Shan, Changliang Dai, Qing Zhang, Liang Xie, Jianxin Gu, Ting-lei Jin, Peng Masa, Aleckovic Leroy, Gary Kang, Yibin Sudderth, Jessica A. Deberardinis, Ralph J. Luan, Chi-hao Chen, Georgia Z. Muller, Susan Shin, Dong M. Owonikoko, Taofeek K. Sagar, Lonial Arellano, Martha L. Khoury, Hanna J. Khuri, Fadlo R. Lee, Benjamin H. Ye, Keqiang Boggon, Titus J. Kang, Sumin He, Chuan Chen, Jing |
| Copyright Year | 2012 |
| Abstract | It remains unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis regulation in part by controlling intracellular levels of its substrate 3-phosphoglycerate (3-PG) and product 2-phosphoglycerate (2-PG). 3-PG binds to and inhibits 6-phosphogluconate dehydrogenase in the oxidative pentose phosphate pathway (PPP), while 2-PG activates 3-phosphoglycerate dehydrogenase to provide feedback control of 3-PG levels. Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth. |
| Related Links | http://dx.doi.org/10.1016/j.ccr.2012.09.020 |
| Ending Page | 600 |
| Page Count | 16 |
| Starting Page | 585 |
| File Format | |
| ISSN | 15356108 |
| e-ISSN | 18783686 |
| Journal | Cancer cell |
| Issue Number | 5 |
| Volume Number | 22 |
| Language | English |
| Publisher Date | 2012-11-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cancer Research Oncology |
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