NDLI: Chemoprevention of benzo(a)pyrene-induced colon polyps in Apc Min mice by resveratrol

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Chemoprevention of benzo(a)pyrene-induced colon polyps in Apc Min mice by resveratrol

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Chemoprevention of benzo(a)pyrene-induced colon polyps in Apc Min mice by resveratrol

Content Provider	PubMed Central
Author	Huderson, Ashley C. Myers, Jeremy N. Niaz, Md. S. Washington, Mary K. Ramesh, Aramandla
Copyright Year	2012
Abstract	Human dietary exposure to benzo(a)pyrene [BaP] has generated interest with regard to the association of BaP with gastrointestinal carcinogenesis. Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression. In this study we investigated the preventive effects of resveratrol (RVT) on BaP-induced colon carcinogenesis in Apc Min mouse model. For the first group of mice, 100 μg BaP/kg bw was administered to mice in peanut oil via oral gavage over a 60 day period. For the second group, RVT was co-administered with BaP at a dose of 45 μg/kg. For the third group, RVT was administered for 1 week prior to BaP exposure for 60 days. Jejunum, colon and liver, were collected at 60 days post-BaP & RVT exposure; adenomas in jejunum and colon were counted and subjected to histopathology. Resveratrol reduced the number of colon adenomas in BaP + RVT-treated mice significantly compared to mice that received BaP alone. While dysplasia of varying degrees was noted in colon of BaP-treated mice, the dysplasias were of limited occurrence in RVT-treated mice. To ascertain whether the tumor inhibition is a result of altered BaP-induced toxicity of tumor cells, growth, apoptosis and proliferation of adenocarcinoma cells were assessed post treatment with RVT and BaP. Co-treatment with RVT increased apoptosis and decreased cell proliferation to a greater extent than with BaP alone. Overall, our observations reveal that RVT inhibits colon tumorigenesis when given together with BaP and holds promise as a therapeutic agent.
Related Links	http://dx.doi.org/10.1016/j.jnutbio.2012.04.005
Ending Page	724
Page Count	12
Starting Page	713
File Format	PDF
ISSN	09552863
e-ISSN	18734847
Journal	The Journal of nutritional biochemistry
Issue Number	4
Volume Number	24
Language	English
Publisher Date	2013-04-01
Access Restriction	Open
Subject Keyword	Nutrition and Dietetics Clinical Biochemistry Biochemistry Molecular Biology Endocrinology, Diabetes and Metabolism Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Molecular Biology Clinical Biochemistry Biochemistry

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