NDLI: T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

Content Provider	PubMed Central
Author	Yin, Lei Crawford, Frances Marrack, Philippa Kappler, John W. Dai, Shaodong
Abstract	T cell-mediated allergy to Ni++ is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni++ is unknown. We studied a TCR from an allergic patient that recognizes Ni++ bound to the MHCII molecule DR52c containing an unknown self-peptide. We identified mimotope peptides that can replace both the self-peptide and Ni++ in this ligand. They share a p7 lysine whose εNH2 group is surface-exposed when bound to DR52c. Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope–DR52c complex, the interface is dominated by the TCR Vβ CDR3 interaction with the p7 lysine. Mutations in the TCR CDR loops have similar effects on the T-cell response to either the mimotope or Ni++ ligand. We suggest that the mimotope p7 lysine mimics Ni++ in the natural TCR ligand and that MHCII β-chain flexibility in the area around the peptide p7 position forms a common site for cation binding in metal allergies.
Related Links	http://dx.doi.org/10.1073/pnas.1215928109
Ending Page	18522
Page Count	6
Starting Page	18517
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	45
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-11-06
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

On TCR binding predictors failing to generalize to unseen peptides

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Empirical and Rational Design of T Cell Receptor-Based Immunotherapies

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition

T-cell antigen receptor (TCR) transmembrane peptides

Localization of T cell receptor (TCR)-gamma delta + T cells into human colorectal cancer: flow cytometric analysis of TCR-gamma delta expression in tumour-infiltrating lymphocytes.

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

Similar Documents

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

On TCR binding predictors failing to generalize to unseen peptides

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Empirical and Rational Design of T Cell Receptor-Based Immunotherapies

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T-cell recognition

T-cell antigen receptor (TCR) transmembrane peptides

Localization of T cell receptor (TCR)-gamma delta + T cells into human colorectal cancer: flow cytometric analysis of TCR-gamma delta expression in tumour-infiltrating lymphocytes.

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy