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| Content Provider | PubMed Central |
|---|---|
| Author | Roy, Anindita Cowan, Gillian Mead, Adam J. Filippi, Sarah Bohn, Georg Chaidos, Aristeidis Tunstall, Oliver Chan, Jerry K. Y. Mahesh, Choolani Bennett, Phillip Kumar, Sailesh Atkinson, Deborah Josephine, Wyatt-ashmead Hu, Ming Stumpf, Michael P. H. Katerina, Goudevenou O'connor, David Chou, Stella T. Weiss, Mitchell J. Anastasios, Karadimitris Jacobsen, Sten Eirik Vyas, Paresh Roberts, Irene |
| Abstract | The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas granulocyte-macrophage progenitors are reduced. Commensurately, HSC and megakaryocyte-erythroid progenitors show higher clonogenicity, with increased megakaryocyte, megakaryocyte-erythroid, and replatable blast colonies. Biased megakaryocyte-erythroid–primed gene expression was detected as early as the HSC compartment. In lymphopoiesis, T21 FL lymphoid-primed multipotential progenitors and early lymphoid progenitor numbers are maintained, but there was a 10-fold reduction in committed PreproB-lymphoid progenitors and the functional B-cell potential of HSC and early lymphoid progenitor is severely impaired, in tandem with reduced early lymphoid gene expression. The same pattern was seen in all T21 FL samples and no samples had GATA1 mutations. Therefore, T21 itself causes multiple distinct defects in FL myelo- and lymphopoiesis. |
| Related Links | http://dx.doi.org/10.1073/pnas.1211405109 |
| Ending Page | 17584 |
| Page Count | 6 |
| Starting Page | 17579 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 43 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-10-23 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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