NDLI: Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1981, Volume: 78, Issue: 12

Year: 1981, Volume: 78, Issue: 11

Year: 1981, Volume: 78, Issue: 10

Steric control of CO binding in a totally synthetic heme protein model

General quantitative treatment for the binding of divalent antibodies to antigens immobilized on a solid phase

Photosensitized electron transfer processes in SiO2 colloids and sodium lauryl sulfate micellar systems: Correlation of quantum yields with interfacial surface potentials

Tropospheric concentrations of methylchloroform, CH3CCl3, in January 1978 and estimates of the atmospheric residence times for hydrohalocarbons

Anomalous dispersion of sulfur in quinidine sulfate, (C20H25N2O2)2SO4·2H2O: Implications for structure analysis

The kinetic energy change on covalent bond formation

Criterion for biholomorphic equivalence of isolated hypersurface singularities

Existence of nonarithmetic monodromy groups

Biosynthesis of vitamin B12: Mode of incorporation of factor III into cobyrinic acid

Evolution of DNA sequence organization in mitochondrial genomes of Zea

Application of differential scanning microcalorimetry to the study of cellular processes: heat production and glucose oxidation of murine macrophages.

Yeast tRNA3Leu gene transcribed and spliced in a HeLa cell extract.

Chicken erythrocyte nucleus contains two classes of chromatin that differ in micrococcal nuclease susceptibility and solubility at physiological ionic strength.

Reinitiation of translation from the triplet next to the amber termination codon in the absence of ribosome-releasing factor.

Asparagine amide metabolism in developing cotyledons of soybean

Molecular cloning of the genome of poliovirus type 1.

Loss of chromosomal high mobility group proteins HMG1 and HMG2 when mouse neuroblastoma and Friend erythroleukemia cells become committed to differentiation.

5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine is an antagonist of the action of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine and double-stranded RNA.

Adult chicken alpha-globin genes alpha A and alpha D: no anemic shock alpha-globin exists in domestic chickens.

mRNA in human cells contains sequences complementary to the Alu family of repeated DNA.

RNAs involved in copy-number control and incompatibility of plasmid R1.

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

Directionality and polarity in recA protein-promoted branch migration.

Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide.

Mechanisms of Kirsten murine sarcoma virus transformation-induced changes in the collagen phenotype and synthetic rate of BALB 3T3 cells.

Cloning of the uvrC gene of Escherichia coli: expression of a DNA repair gene.

Two periplasmic transport proteins which interact with a common membrane receptor show extensive homology: complete nucleotide sequences.

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

Fluorometric assay for adenosine 3',5'-cyclic monophosphate-dependent protein kinase and phosphoprotein phosphatase activities.

Posttranslational processing of methyl-accepting chemotaxis proteins in Escherichia coli

Synthesis, intracellular transport, and processing of the precursors for mitochondrial ornithine transcarbamylase and carbamoyl-phosphate synthetase I in isolated hepatocytes.

tif-1 mutation alters polynucleotide recognition by the recA protein of Escherichia coli.

Membrane potential depolarization and increased intracellular pH accompany the acrosome reaction of sea urchin sperm.

Membrane glycoproteins involved in cell--substratum adhesion.

Structure of the zeta chain of human embryonic hemoglobin.

Use of whole-cell fixation to visualize replicating and maturing simian virus 40: identification of new viral gene product.

The M r 80,000 common forms of neurophysin and vasopressin from bovine neurohypophysis have corticotropin- and β-endorphin-like sequences and liberate by proteolysis biologically active corticotropin

Synthesis of stable unspliced mRNA from an intronless simian virus 40--rat preproinsulin gene recombinant.

Plasmid ColE1 incompatibility determined by interaction of RNA I with primer transcript.

Conformational transition in the myosin hinge upon activation of muscle.

Isolation of the Escherichia coli leader peptidase gene and effects of leader peptidase overproduction in vivo.

Escherichia coli factor Y sites of plasmid pBR322 can function as origins of DNA replication.

Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences.

Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

32P-labeling test for DNA damage.

Low molecular weight RNAs transcribed in vitro by RNA polymerase III from Alu-type dispersed repeats in Chinese hamster DNA are also found in vivo.

Human somatotropin: covalent reconstitution of two polypeptide contiguous fragments with thrombin.

Uninfected cell polymerase efficiently transcribes early but not late herpes simplex virus type 1 mRNA.

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

Heteroduplex formation by recA protein: polarity of strand exchanges.

Molecular complexes involved in the regulation of adenylate cyclase.

Regulation of protein synthesis: translational control by procollagen-derived fragments.

Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD.

Preparation of tritium- or deuterium-labeled vitamin D analogs by a convenient general method *

Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: reconstitution by hybridization.

Classification of multiple morphine and enkephalin binding sites in the central nervous system.

Amino acid sequence of a human leukocyte interferon.

Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.

DNA sequence analysis reveals extensive homologies of regions preceding hsp70 and αβ heat shock genes in Drosophila melanogaster

Pathway of protein glycosylation in the trypanosomatid Crithidia fasciculata.

Synthesis of parvovirus H-1 replicative form from viral DNA by DNA polymerase gamma.

Effect of surface modification on aggregation of phospholipid vesicles.

Coordination environment of the active-site metal ion of liver alcohol dehydrogenase.

Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.

Involvement of trypsin-like activity in binding of mouse spermatozoa to zonae pellucidae.

Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts.

Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.

Rate of lateral diffusion of intramembrane particles: measurement by electrophoretic displacement and rerandomization.

Metabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formation.

Lectins activate lymphocyte pyruvate dehydrogenase by a mechanism sensitive to protease inhibitors.

Fibronectin-like protein in Porifera: its role in cell aggregation.

Effect of vinblastine on distribution of murine leukemia virus-derived membrane-associated antigens.

pH homeostasis in Escherichia coli: measurement by 31P nuclear magnetic resonance of methylphosphonate and phosphate.

Mapping functional domains in the promoter region of the herpes thymidine kinase gene.

Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture.

Reactivation of chicken erythrocyte nuclei in heterokaryons results in expression of adult chicken globin genes.

5-Azacytidine induction of mouse endogenous type C virus and suppression of DNA methylation.

Most of the G1 period in hamster cells is eliminated by lengthening the S period.

Membrane differentiation in human myeloid cells: expression of unique profiles of cell surface glycoproteins in myeloid leukemic cell lines blocked at different stages of differentiation and maturation.

Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists.

Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis.

Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells

Extensive polymorphism in the mitochondrial DNA of apes.

Structured habitats and the evolution of anticompetitor toxins in bacteria.

The cyc1-11 mutation in yeast reverts by recombination with a nonallelic gene: composite genes determining the iso-cytochromes c.

Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse.

Potential for selection among nearly neutral allozymes of 6-phosphogluconate dehydrogenase in Escherichia coli.

A general high-efficiency procedure for production of microcell hybrids.

Yeast transformation: a model system for the study of recombination.

Genetic control of insulin receptors.

Mouse alpha-globin genes and alpha-globin-like pseudogenes are not syntenic.

Molecular cloning of a mouse submaxillary gland renin cDNA fragment.

Molecular basis for familial isolated growth hormone deficiency.

Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring.

Longer-than-unit-length viroid minus strands are present in RNA from infected plants

Transcription of the simian virus 40 genome in DNA-transformed murine teratocarcinoma stem cells.

Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity.

Selective natural killer resistance in a clone of YAC lymphoma cells.

Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction.

Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Characterization of T-cell surface proteins bound by heterologous antisera to antigen-specific T-cell products.

Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment.

Single channel currents induced by complement in antibody-coated cell membranes.

Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers.

Functional helper activity of monoclonal T cell populations: antigen-specific and H-2 restricted cloned T cells provide help for in vitro antibody responses to trinitrophenyl-poly(LTyr,Glu)-poly(DLAla)--poly(LLys).

Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA.

Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate.

Episomal simian virus 40 genomes in human brain tumors.

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from patients with Huntington disease, familial dysautonomia, and other primary neuronal degenerations.

Expression of major histocompatibility antigens on pancreatic islet cells.

Herpes simplex type 1 DNA in human brain tissue.

Protein variations associated with Lesch-Nyhan syndrome.

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

Increased ascorbic acid content in chronic lymphocytic leukemia B lymphocytes.

Monoclonal antibody against a Burkitt lymphoma-associated antigen.

alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-N-methylaniline.

Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion.

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

Manifold expression of new cellular genes in human lymphoid neoplasia.

Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone.

Amygdalin (Laetrile) and prunasin beta-glucosidases: distribution in germ-free rat and in human tumor tissue.

Primary structure of corticotropin-releasing factor from ovine hypothalamus.

Repression and activation of the genome of herpes simplex viruses in human cells.

Clones of the malaria parasite Plasmodium falciparum obtained by microscopic selection: their characterization with regard to knobs, chloroquine sensitivity, and formation of gametocytes.

Dopaminergic modulation of adenylate cyclase stimulation by vasoactive intestinal peptide in anterior pituitary.

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

Linear information processing in the retina: a study of horizontal cell responses.

Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

Abnormal action potentials associated with the Shaker complex locus of Drosophila

Immunocytochemical localization of aspartate aminotransferase immunoreactivity in cochlear nucleus of the guinea pig.

Marginal underdominance at a stable equilibrium

β-Endorphin: Characteristics of binding sites in a neuroblastoma-glioma hybrid cell

Galloping induced by pontine tegmentum damage in rats: A form of “Parkinsonian festination” not blocked by haloperidol

Year: 1981, Volume: 78, Issue: 9

Year: 1981, Volume: 78, Issue: 8

Year: 1981, Volume: 78, Issue: 7

Year: 1981, Volume: 78, Issue: 6

Year: 1981, Volume: 78, Issue: 5

Year: 1981, Volume: 78, Issue: 4

Year: 1981, Volume: 78, Issue: 3

Year: 1981, Volume: 78, Issue: 2

Year: 1981, Volume: 78, Issue: 1

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Content Provider	PubMed Central
Author	Lin, C. C. Rosenthal, A. S. Passmore, H. C. Hansen, T. H.
Abstract	Immune responses to several soluble antigens were compared between B6.C-H-2bm12 mutant and wild-type B6 mice by using a lymph node T-cell proliferation assay. B6.C-H-2bm12 mice failed to respond to beef insulin whereas other IA gene-controlled responses, such as response to poly(L-Tyr, L-Glu)--poly(DL-Ala, L-Lys) and collagen, were indistinguishable between mutant and wild-type mice. The responses to multideterminant antigens such as ovalbumin and purified protein derivative of tuberculin were also found to be comparable in B6.C-H-2bm12 and B6 mice, thus indicating that this mutation resulted in a selective loss of the ability to respond to a certain antigen(s)--e.g., beef insulin. Populations depleted of adherent cells have been used to examine the mechanism by which Ia molecules mediate Ir gene control of antigen recognition. We show that the nonresponsiveness to beef insulin in the mutant mouse is the result of defective antigen presentation. In addition, we find that F1 hybrids between two nonresponders--B6.C-H-2bm12 and B10.A or B10.AKM (IAk) mice--become responders to beef insulin, thus demonstrating gene complementation. These findings taken together with other serologic and biochemical studies in the B6.C-H-2bm12 present convincing genetic evidence for the direct association of the A beta polypeptide chain of the Iab molecules with the expression of immune responsiveness to beef insulin. Study of the B6.C-H-2bm12 mouse should provide new insight into the cellular and molecular mechanisms by which Ir genes determine the nature of the immune response.
Starting Page	6406
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	78
Language	English
Publisher Date	1981-10-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in