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| Content Provider | PubMed Central |
|---|---|
| Author | Sefton, Bartholomew M. Hunter, Tony Beemon, Karen |
| Abstract | All vertebrate cells have been shown to contain a gene, sarc, that has some homology with the transforming gene of Rous sarcoma virus, src. We have compared the polypeptide products of the sarc gene, p60 sarc , of human, mouse, and chicken cells with the polymorphic polypeptide product of the src gene, p60 src , of several strains of Rous sarcoma virus by two-dimensional peptide mapping. p60 sarc from chicken cells was clearly related to every viral p60 src . Eleven of its 13 methionine-containing tryptic peptides were present in some viral p60 src . Conversely, the other two peptides were not present in any p60 src we have examined so far. The 11 peptides from p60 sarc of chickens that were shared with viral p60 src , however, were not all present in any single viral p60 src . These 11 peptides most closely resemble those in the p60 src s of B77 virus and the Prague strain of Rous sarcoma virus. These data are consistent with the hypothesis that cellular sarc is the progenitor of viral src. The p60 sarc s of human, mouse, and chicken cells were so similar in tryptic peptide composition that they were more closely related to each other than were some viral p60 src s. The two mammalian p60 sarc s differed from avian p60 sarc most notably in that they lacked a peptide that chicken p60 sarc shares with all the viral p60 src s. The similarity of these maps suggests that the sequence of the p60 sarc polypeptide has diverged very little during evolution. This may imply that p60 sarc is an essential cellular component. |
| Starting Page | 2059 |
| File Format | |
| ISSN | 10916490 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 77 |
| Language | English |
| Publisher Date | 1980-04-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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