NDLI: Experimental and clinical evidence of antioxidant therapy in acute pancreatitis

Content Provider	PubMed Central
Author	Esrefoglu, Mukaddes
Copyright Year	2012
Abstract	Oxidative stress has been shown to play an important role in the pathogenesis of acute pancreatitis (AP). Antioxidants, alone or in combination with conventional therapy, should improve oxidative-stress-induced organ damage and therefore accelerate the rate of recovery. In recent years, substantial amounts of data about the efficiency of antioxidants against oxidative damage have been obtained from experiments with rodents. Some of these antioxidants have been found beneficial in the treatment of AP in humans; however, at present there is insufficient clinical data to support the benefits of antioxidants, alone or in combination with conventional therapy, in the management of AP in humans. Conflicting results obtained from experimental animals and humans may represent distinct pathophysiological mechanisms mediating tissue injury in different species. Further detailed studies should be done to clarify the exact mechanisms of tissue injury in human AP. Herein I tried to review the existing experimental and clinical studies on AP in order to determine the efficiency of antioxidants. The use of antioxidant enriched nutrition is a potential direction of clinical research in AP given the lack of clues about the efficiency and safety of antioxidant usage in patients with AP.
Related Links	http://dx.doi.org/10.3748/wjg.v18.i39.5533
Starting Page	5533
File Format	PDF
ISSN	10079327
Journal	World Journal of Gastroenterology : WJG
Issue Number	39
Volume Number	18
Language	English
Publisher	Baishideng Publishing Group Co., Limited
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Co., Limited
Subject Keyword	Gastroenterology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Experimental evidence of obesity as a risk factor for severe acute pancreatitis

Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: A systematic review

Safety and Efficacy of Vitamin-based Antioxidant Therapy in Patients with Severe Acute Pancreatitis: A Randomized Controlled Trial

Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis

Therapeutic proteasome inhibition in experimental acute pancreatitis

Pharmacologic therapy for acute pancreatitis

Stress kinase inhibition modulates acute experimental pancreatitis

Endoscopic therapy in acute recurrent pancreatitis

Randomised, double blind, placebo controlled trial of intravenous antioxidant (n‐acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis

Experimental and clinical evidence of antioxidant therapy in acute pancreatitis

Similar Documents

Experimental evidence of obesity as a risk factor for severe acute pancreatitis

Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: A systematic review

Safety and Efficacy of Vitamin-based Antioxidant Therapy in Patients with Severe Acute Pancreatitis: A Randomized Controlled Trial

Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis

Therapeutic proteasome inhibition in experimental acute pancreatitis

Pharmacologic therapy for acute pancreatitis

Stress kinase inhibition modulates acute experimental pancreatitis

Endoscopic therapy in acute recurrent pancreatitis

Randomised, double blind, placebo controlled trial of intravenous antioxidant (n‐acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis

Experimental and clinical evidence of antioxidant therapy in acute pancreatitis