NDLI: Drug Repurposing: Far Beyond New Targets for Old Drugs

Please wait, while we are loading the content...

A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS

Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics

International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States

ADME of Antibody–Maytansinoid Conjugates

Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site

Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations

Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective

Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells

Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development

Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice

Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules

Effective Absorption Modeling in Relative Bioavailability Study Risk Assessment

Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats

Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations

Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact

Year: 2012, Volume: 14, Issue: 3

Year: 2012, Volume: 14, Issue: 2

Year: 2012, Volume: 14, Issue: 1

Year: 2011, Volume: 14

Year: 2011, Volume: 13

Year: 2010, Volume: 13

Year: 2010, Volume: 12

Year: 2009, Volume: 12

Year: 2009, Volume: 11

Year: 2008, Volume: 10

Year: 2007, Volume: 9

Year: 2006, Volume: 8

Year: 2005, Volume: 7

Year: 2004, Volume: 6

Drug Repurposing: Far Beyond New Targets for Old Drugs

Content Provider	PubMed Central
Author	Oprea, T. I. Mestres, J.
Abstract	Repurposing drugs requires finding novel therapeutic indications compared to the ones for which they were already approved. This is an increasingly utilized strategy for finding novel medicines, one that capitalizes on previous investments while derisking clinical activities. This approach is of interest primarily because we continue to face significant gaps in the drug–target interactions matrix and to accumulate safety and efficacy data during clinical studies. Collecting and making publicly available as much data as possible on the target profile of drugs offer opportunities for drug repurposing, but may limit the commercial applications by patent applications. Certain clinical applications may be more feasible for repurposing than others because of marked differences in side effect tolerance. Other factors that ought to be considered when assessing drug repurposing opportunities include relevance to the disease in question and the intellectual property landscape. These activities go far beyond the identification of new targets for old drugs.
Related Links	http://dx.doi.org/10.1208/s12248-012-9390-1
Ending Page	763
Page Count	5
Starting Page	759
File Format	PDF
ISSN	15507416
e-ISSN	15507416
Journal	The AAPS Journal
Issue Number	4
Volume Number	14
Language	English
Publisher	Springer US
Publisher Date	2012-12-01
Access Restriction	Open
Rights Holder	Springer US
Subject Keyword	Pharmaceutical Science Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Drug Repurposing: Far Beyond New Targets for Old Drugs

NSAIDs: Old Drugs Reveal New Anticancer Targets

Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs

Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?

Repurposing Old Drugs for New Uses

Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing

Old drugs, new challenges: reassigning drugs for cancer therapies

Auranofin: Repurposing an Old Drug for a Golden New Age

Paclitaxel: new uses for an old drug

Drug Repurposing: Far Beyond New Targets for Old Drugs

Similar Documents

Drug Repurposing: Far Beyond New Targets for Old Drugs

NSAIDs: Old Drugs Reveal New Anticancer Targets

Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs

Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?

Repurposing Old Drugs for New Uses

Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing

Old drugs, new challenges: reassigning drugs for cancer therapies

Auranofin: Repurposing an Old Drug for a Golden New Age

Paclitaxel: new uses for an old drug

Drug Repurposing: Far Beyond New Targets for Old Drugs