NDLI: Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

Content Provider	PubMed Central
Author	Lee, Jeong-sook Park, Ah Hyung Lee, Sang-hee Lee, Seoung-hoon Kim, Jin-hwan Yang, Suk-jin Yeom, Young Il Kwak, Tae Hwan Lee, Dongyeop Lee, Seung-jae Lee, Chul-ho Kim, Jin Man Kim, Daesoo
Editor	Bai, Yidong
Copyright Year	2012
Abstract	NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD+/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding β-lapachone (βL), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. βL-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and decreased in the muscles of control diet group but those defects were less severe in βL-fed aged mice. Furthermore, for a subset of genes associated with energy metabolism, mice fed the βL-diet showed similar changes in gene expression to the CR group (fed 70% of the control diet). These results support the potentiation of NQO1 activity by a βL diet and could be an option for preventing age-related decline of muscle and brain functions.
Related Links	http://dx.doi.org/10.1371/journal.pone.0047122
Starting Page	47122
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	10
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-10-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice

Mushroom Ganoderma lucidum Prevents Colitis-Associated Carcinogenesis in Mice

Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice

C17 Prevents Inflammatory Arthritis and Associated Joint Destruction in Mice

Dietary Resveratrol Prevents the Development of Food Allergy in Mice

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

Inhibition of Aldose Reductase Prevents Experimental Allergic Airway Inflammation in Mice

Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

Similar Documents

β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice

Mushroom Ganoderma lucidum Prevents Colitis-Associated Carcinogenesis in Mice

Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice

C17 Prevents Inflammatory Arthritis and Associated Joint Destruction in Mice

Dietary Resveratrol Prevents the Development of Food Allergy in Mice

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

Inhibition of Aldose Reductase Prevents Experimental Allergic Airway Inflammation in Mice

Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice