NDLI: Beyond the rodent model: Calorie restriction in rhesus monkeys

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Beyond the rodent model: Calorie restriction in rhesus monkeys

Content Provider	PubMed Central
Author	Lane, Mark A. Ingram, Donald K. Roth, George S.
Abstract	Lifespan extension and reduction of age-related disease by calorie restriction (CR) are among the most consistent findings in gerontological research. The well known effects of CR have been demonstrated many times in rodents and other short-lived species. However, effects of CR on aging in longer-lived species, more closely related to humans, were unknown until recently. Studies of CR and aging using nonhuman primates (rhesus monkeys) were begun several years ago at the National Institute on Aging, the University of Wisconsin-Madison, and the University of Maryland. These studies are beginning to yield useful data regarding the effects of this nutritional intervention in primates. Several studies from these ongoing investigations have shown that rhesus monkeys on CR exhibit physiological responses to CR that parallel findings in rodents. In addition, several potential biomarkers of aging are being evaluated and preliminary findings suggest the possibility that CR in rhesus monkeys could slow the rate of aging and reduce age-related disease, specifically diabetes and cardiovascular disease. It will be several years before conclusive proof that CR slows aging and extends life span in primates is established, however, results from these exciting studies suggest the possibility that the anti-aging effects of CR reported in rodents also occur in longer-lived species such as nonhuman primates, strenghtening the possibility that this nutritional intervention will also prove beneficial in longer-lived species, including humans.
Related Links	http://dx.doi.org/10.1007/s11357-997-0004-2
Ending Page	56
Page Count	12
Starting Page	45
File Format	PDF
ISSN	01619152
Journal	Age
Issue Number	1
Volume Number	20
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1997-01-01
Access Restriction	Open
Rights Holder	Kluwer Academic Publishers
Subject Keyword	Ageing Geriatrics and Gerontology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology

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