NDLI: Shaping of object representations in the human medial temporal lobe based on temporal regularities

Content Provider	PubMed Central
Author	Schapiro, Anna C. Kustner, Lauren V. Turk-browne, Nicholas B.
Copyright Year	2012
Abstract	Regularities are gradually represented in cortex after extensive experience [1], and yet they can influence behavior after minimal exposure [2,3]. What kind of representations support such rapid statistical learning? The medial temporal lobe (MTL) can represent information from even a single experience [4], making it a good candidate system for assisting in initial learning about regularities. We combined anatomical segmentation of the MTL, high-resolution functional magnetic resonance imaging (fMRI), and multivariate pattern analysis (MVPA) to identify representations of objects in cortical and hippocampal areas of human MTL, assessing how these representations were shaped by exposure to regularities. Subjects viewed a continuous visual stream containing hidden temporal relationships—pairs of objects that reliably appeared nearby in time. We compared the pattern of blood oxygen level-dependent (BOLD) activity evoked by each object before and after this exposure, and found that perirhinal cortex (PRC), parahippocampal cortex (PHC), subiculum, CA1, and CA2/CA3/dentate gyrus (CA2/3/DG) encoded regularities by increasing the representational similarity of their constituent objects. Most regions exhibited bidirectional associative shaping, while CA2/3/DG represented regularities in a forward-looking predictive manner. These findings suggest that object representations in MTL come to mirror the temporal structure of the environment, supporting rapid and incidental statistical learning.
Related Links	http://dx.doi.org/10.1016/j.cub.2012.06.056
Ending Page	1627
Page Count	6
Starting Page	1622
File Format	PDF
ISSN	09609822
e-ISSN	18790445
Journal	Current biology : CB
Issue Number	17
Volume Number	22
Language	English
Publisher Date	2012-09-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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