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| Content Provider | PubMed Central |
|---|---|
| Author | Çevik, Volkan Kidd, Brendan N. Zhang, Peijun Hill, Claire Kiddle, Steve Denby, Katherine J. Holub, Eric B. Cahill, David M. Manners, John M. Schenk, Peer M. Beynon, Jim Kazan, Kemal |
| Copyright Year | 2012 |
| Abstract | The PHYTOCHROME AND FLOWERING TIME1 gene encoding the MEDIATOR25 (MED25) subunit of the eukaryotic Mediator complex is a positive regulator of jasmonate (JA)-responsive gene expression in Arabidopsis (Arabidopsis thaliana). Based on the function of the Mediator complex as a bridge between DNA-bound transcriptional activators and the RNA polymerase II complex, MED25 has been hypothesized to function in association with transcriptional regulators of the JA pathway. However, it is currently not known mechanistically how MED25 functions to regulate JA-responsive gene expression. In this study, we show that MED25 physically interacts with several key transcriptional regulators of the JA signaling pathway, including the APETALA2 (AP2)/ETHYLENE RESPONSE FACTOR (ERF) transcription factors OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59 and ERF1 as well as the master regulator MYC2. Physical interaction detected between MED25 and four group IX AP2/ERF transcription factors was shown to require the activator interaction domain of MED25 as well as the recently discovered Conserved Motif IX-1/EDLL transcription activation motif of MED25-interacting AP2/ERFs. Using transcriptional activation experiments, we also show that OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59- and ERF1-dependent activation of PLANT DEFENSIN1.2 as well as MYC2-dependent activation of VEGETATIVE STORAGE PROTEIN1 requires a functional MED25. In addition, MED25 is required for MYC2-dependent repression of pathogen defense genes. These results suggest an important role for MED25 as an integrative hub within the Mediator complex during the regulation of JA-associated gene expression. |
| Related Links | http://dx.doi.org/10.1104/pp.112.202697 |
| Ending Page | 555 |
| Page Count | 15 |
| Starting Page | 541 |
| File Format | |
| ISSN | 00320889 |
| e-ISSN | 15322548 |
| Journal | Plant Physiology |
| Issue Number | 1 |
| Volume Number | 160 |
| Language | English |
| Publisher | American Society of Plant Biologists |
| Publisher Date | 2012-09-01 |
| Access Restriction | Open |
| Rights Holder | American Society of Plant Biologists |
| Subject Keyword | Plant Science Genetics Physiology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Physiology Plant Science |
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