NDLI: Nucleolar Dominance of the Y Chromosome in Drosophila melanogaster

Content Provider	PubMed Central
Author	Greil, Frauke Ahmad, Kami
Copyright Year	2012
Abstract	The rDNA genes are transcribed by RNA polymerase I to make structural RNAs for ribosomes. Hundreds of rDNA genes are typically arranged in an array that spans megabase pairs of DNA. These arrays are the major sites of transcription in growing cells, accounting for as much as 50% of RNA synthesis. The repetitive rDNA arrays are thought to use heterochromatic gene silencing as a mechanism for metabolic regulation, since repeated sequences nucleate heterochromatin formation in eukaryotes. Drosophila melanogaster carries an rDNA array on the X chromosome and on the Y chromosome, and genetic analysis has suggested that both are transcribed. However, using a chromatin-marking assay, we find that the entire X chromosome rDNA array is normally silenced in D. melanogaster males, while the Y chromosome rDNA array is dominant and expressed. This resembles “nucleolar dominance,” a phenomenon that occurs in interspecific hybrids where an rDNA array from one parental species is silenced, and that from the other parent is preferentially transcribed. Interspecies nucleolar dominance is thought to result from incompatibilities between species-specific transcription factors and the rDNA promoters in the hybrid, but our results show that nucleolar dominance is a normal feature of rDNA regulation. Nucleolar dominance within D. melanogaster is only partially dependent on known components of heterochromatic gene silencing, implying that a distinctive chromatin regulatory system may act at rDNA genes. Finally, we isolate variant Y chromosomes that allow X chromosome array expression and suggest that the large-scale organization of rDNA arrays contribute to nucleolar dominance. This is the first example of allelic inactivation in D. melanogaster.
Related Links	http://dx.doi.org/10.1534/genetics.112.141242
Ending Page	1128
Page Count	10
Starting Page	1119
File Format	PDF
ISSN	00166731
e-ISSN	19432631
Journal	Genetics
Issue Number	4
Volume Number	191
Language	English
Publisher	Genetics Society of America
Publisher Date	2012-08-01
Access Restriction	Open
Rights Holder	Genetics Society of America
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.

Y Chromosome Loops in Drosophila Melanogaster

The Genetic and Cytological Organization of the Y Chromosome of DROSOPHILA MELANOGASTER

The Structure of the Y Chromosome in the Salivary Glands of Drosophila Melanogaster

The Structure of the Y Chromosome in the Salivary Glands of Drosophila Melanogaster

Functional Copies of the Mst77F Gene on the Y Chromosome of Drosophila melanogaster

Cytogenetic Analysis of a Segment of the Y Chromosome of DROSOPHILA MELANOGASTER

Imprinting of the Y Chromosome Influences Dosage Compensation in roX1 roX2 Drosophila melanogaster

Nucleolar Dominance and Replicative Dominance in Drosophila Interspecific Hybrids

Nucleolar Dominance of the Y Chromosome in Drosophila melanogaster

Similar Documents

The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.

Y Chromosome Loops in Drosophila Melanogaster

The Genetic and Cytological Organization of the Y Chromosome of DROSOPHILA MELANOGASTER

The Structure of the Y Chromosome in the Salivary Glands of Drosophila Melanogaster

The Structure of the Y Chromosome in the Salivary Glands of Drosophila Melanogaster

Functional Copies of the Mst77F Gene on the Y Chromosome of Drosophila melanogaster

Cytogenetic Analysis of a Segment of the Y Chromosome of DROSOPHILA MELANOGASTER

Imprinting of the Y Chromosome Influences Dosage Compensation in roX1 roX2 Drosophila melanogaster

Nucleolar Dominance and Replicative Dominance in Drosophila Interspecific Hybrids

Nucleolar Dominance of the Y Chromosome in Drosophila melanogaster