NDLI: Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer

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Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer

Content Provider	PubMed Central
Author	Chari, Raj Thu, Kelsie L. Wilson, Ian M. Lockwood, William W. Lonergan, Kim M. Coe, Bradley P. Malloff, Chad A. Gazdar, Adi F. Lam, Stephen Cathie, Garnis Macaulay, Calum E. Alvarez, Carlos E. Lam, Wan L.
Copyright Year	2010
Abstract	Advances in high-throughput, genome-wide profiling technologies have allowed for an unprecedented view of the cancer genome landscape. Specifically, high-density microarrays and sequencing-based strategies have been widely utilized to identify genetic (such as gene dosage, allelic status, and mutations in gene sequence) and epigenetic (such as DNA methylation, histone modification, and micro-RNA) aberrations in cancer. Although the application of these profiling technologies in unidimensional analyses has been instrumental in cancer gene discovery, genes affected by low-frequency events are often overlooked. The integrative approach of analyzing parallel dimensions has enabled the identification of (a) genes that are often disrupted by multiple mechanisms but at low frequencies by any one mechanism and (b) pathways that are often disrupted at multiple components but at low frequencies at individual components. These benefits of using an integrative approach illustrate the concept that the whole is greater than the sum of its parts. As efforts have now turned toward parallel and integrative multidimensional approaches for studying the cancer genome landscape in hopes of obtaining a more insightful understanding of the key genes and pathways driving cancer cells, this review describes key findings disseminating from such high-throughput, integrative analyses, including contributions to our understanding of causative genetic events in cancer cell biology.
Related Links	http://dx.doi.org/10.1007/s10555-010-9199-2
Ending Page	93
Page Count	21
Starting Page	73
File Format	PDF
ISSN	01677659
e-ISSN	15737233
Journal	Cancer metastasis reviews
Issue Number	1
Volume Number	29
Language	English
Publisher Date	2010-03-01
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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