NDLI: Unexpected role for MHC II–peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo

Content Provider	PubMed Central
Author	Do, Jeong-su Anna, Valujskikh Vignali, Dario A. A. Fairchild, Robert L. Min, Booki
Abstract	Here we report a unique role for MHC II–peptide complexes in controlling immune responses of naïve CD8 T cells. Compared with CD8 T cells from WT mice, CD8 T cells isolated from MHC II−/− mice hyperproliferated under lymphopenic conditions, differentiated into effector cells producing proinflammatory cytokines, and mediated more severe tissue inflammation. The elevated responses of MHC II−/− CD8 T cells were due to the absence of MHC II, but not CD4, T cells. The hyperreactivity appeared to be a feature of mature T cells, given its absence in CD8 single positive thymocytes derived from MHC II−/− mice. Expression of the MHC II ligand LAG3 was markedly enhanced during in vivo activation of MHC II−/− CD8 T cells, and blockade of MHC II–LAG3 interactions further enhanced T-cell expansion. Importantly, CD8 T cells isolated from H-2M−/− mice expressing WT levels of MHC II also displayed hyperresponsiveness similar to that of MHC II−/− CD8 T cells, suggesting that peptides presented on MHC II are involved in the control of CD8 T-cell responses. Our results uncover a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity and may have implications for an improved understanding of CD8 T-cell homeostasis and functions.
Related Links	http://dx.doi.org/10.1073/pnas.1207219109
Ending Page	12703
Page Count	6
Starting Page	12698
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	31
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-07-31
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.

Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8+ T cells expressing the same or different T cell receptors

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