NDLI: Sushi domains confer distinct trafficking profiles on GABAB receptors

Content Provider	PubMed Central
Author	Hannan, Saad Wilkins, Megan E. Smart, Trevor G.
Abstract	GABAB receptors mediate slow inhibitory neurotransmission in the brain and feature during excitatory synaptic plasticity, as well as various neurological conditions. These receptors are obligate heterodimers composed of GABABR1 and R2 subunits. The two predominant R1 isoforms differ by the presence of two complement control protein modules or Sushi domains (SDs) in the N terminus of R1a. By using live imaging, with an α-bungarotoxin-binding site (BBS) and fluorophore-linked bungarotoxin, we studied how R2 stabilizes R1b subunits at the cell surface. Heterodimerization with R2 reduced the rate of internalization of R1b, compared with R1b homomers. However, R1aR2 heteromers exhibited increased cell surface stability compared with R1bR2 receptors in hippocampal neurons, suggesting that for receptors containing the R1a subunit, the SDs play an additional role in the surface stability of GABAB receptors. Both SDs were necessary to increase the stability of R1aR2 because single deletions caused the receptors to be internalized at the same rate and extent as R1bR2 receptors. Consistent with these findings, a chimera formed from the metabotropic glutamate receptor (mGluR)2 and the SDs from R1a increased the surface stability of mGluR2. These results suggest a role for SDs in stabilizing cell surface receptors that could impart different pre- and postsynaptic trafficking itineraries on GABAB receptors, thereby contributing to their physiological and pathological roles.
Related Links	http://dx.doi.org/10.1073/pnas.1201660109
Ending Page	12176
Page Count	6
Starting Page	12171
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	30
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-07-24
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Sushi domains confer distinct trafficking profiles on GABAB receptors.

The Sushi Domains of Secreted GABAB1 Isoforms Selectively Impair GABAB Heteroreceptor Function* S⃞

Modulation of cell surface GABAB receptors by desensitization, trafficking and regulated degradation

Functional modulation of GABAB receptors by protein kinases and receptor trafficking

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors

TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains

Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors

The Sushi Domains of Secreted GABAB1 Isoforms Selectively Impair GABAB Heteroreceptor Function

Sushi domains confer distinct trafficking profiles on GABAB receptors

Similar Documents

Sushi domains confer distinct trafficking profiles on GABAB receptors.

The Sushi Domains of Secreted GABAB1 Isoforms Selectively Impair GABAB Heteroreceptor Function* S⃞

Modulation of cell surface GABAB receptors by desensitization, trafficking and regulated degradation

Functional modulation of GABAB receptors by protein kinases and receptor trafficking

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors

TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains

Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors

The Sushi Domains of Secreted GABAB1 Isoforms Selectively Impair GABAB Heteroreceptor Function

Sushi domains confer distinct trafficking profiles on GABAB receptors