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| Content Provider | PubMed Central |
|---|---|
| Author | Arias, Irwin M. |
| Copyright Year | 2012 |
| Abstract | In the 1960s, my lab was interested in understanding how bilirubin and other organic anions are transferred from the plasma through the liver cell and into the bile. We performed gel filtration of liver supernatants and identified two protein fractions, designated Y and Z, which bound organic anions including bilirubin, and thus we proposed that they were involved in hepatic uptake of organic anions from plasma. Subsequently, the Y and Z proteins responsible for this binding activity were purified, cloned, and sequenced. Y was identified as a member of the glutathione S-transferase (GST) protein family and Z found to be a member of the fatty acid–binding protein (FABP) family. These proteins have since been shown to have additional surprising roles, but understanding of their full role in physiology and disease has not yet been achieved. |
| Related Links | http://dx.doi.org/10.1172/JCI64587 |
| Starting Page | 2763 |
| File Format | |
| ISSN | 15588238 |
| e-ISSN | 15588238 |
| Journal | The Journal of Clinical Investigation |
| Issue Number | 8 |
| Volume Number | 122 |
| Language | English |
| Publisher | American Society for Clinical Investigation |
| Publisher Date | 2012-08-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Clinical Investigation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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