NDLI: Altered Structural Connectivity in Neonates at Genetic Risk for Schizophrenia: A Combined Study Using Morphological and White Matter Networks

Content Provider	PubMed Central
Author	Shi, Feng Yap, Pew-thian Gao, Wei Lin, Weili Gilmore, John H. Shen, Dinggang
Copyright Year	2012
Abstract	Recently, an increasing body of evidence suggests that developmental abnormalities related to schizophrenia may occur as early as the neonatal stage. Impairments of brain gray matter and wiring problems of axonal fibers are commonly suspected to be responsible for the disconnection hypothesis in schizophrenia adults, but significantly less is known in neonates. In this study, we investigated 26 neonates who were at genetic risk for schizophrenia and 26 demographically matched healthy neonates using both morphological and white matter networks to examine possible brain connectivity abnormalities. The results showed that both populations exhibited small-world network topology. Morphological network analysis indicated that the brain structural associations of the high-risk neonates tended to have globally lower efficiency, longer connection distance, and less number of hub nodes and edges with relatively higher betweenness. Subgroup analysis showed that male neonates were significantly disease-affected, while the female neonates were not. White matter network analysis, however, showed that the fiber networks were globally unaffected, although several subcortical-cortical connections had significantly less number of fibers in high-risk neonates. This study provides new evidences in support of the disconnection hypothesis, reinforcing the notion that the genetic risk of schizophrenia induces alterations in both gray matter structural associations and white matter connectivity.
Related Links	http://dx.doi.org/10.1016/j.neuroimage.2012.05.026
Ending Page	1633
Page Count	12
Starting Page	1622
File Format	PDF
ISSN	10538119
e-ISSN	10959572
Journal	NeuroImage
Issue Number	3
Volume Number	62
Language	English
Publisher Date	2012-09-01
Access Restriction	Open
Subject Keyword	Cognitive Neuroscience Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Cognitive Neuroscience

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