NDLI: Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents’ Trajectories of Anxious/Depressed Symptoms

Content Provider	PubMed Central
Author	Petersen, Isaac T. Bates, John E. Goodnight, Jackson A. Dodge, Kenneth A. Lansford, Jennifer E. Pettit, Gregory S. Latendresse, Shawn J. Dick, Danielle M.
Copyright Year	2012
Abstract	Caspi et al. (2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents’ trajectories of anxious/depressed symptoms, with consideration of possible age effects. Adolescents (N = 574), of whom 436 were genotyped, were followed from ages 12 to 17. Analyses demonstrated a G × E interaction in predicting the development of anxious/depressed symptoms. Specifically, adolescents with lower serotonin transcriptional efficiency (TE) genotypes whose mothers reported more stressful events were reported to show more anxious/depressed symptoms and greater increases in the development of symptoms of anxiety and depression than were higher TE adolescents, particularly at ages 16 and 17. Interactions did not differ by gender. Findings demonstrate that stress may affect adolescents’ likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence.
Related Links	http://dx.doi.org/10.1037/a0027471
Ending Page	1475
Page Count	13
Starting Page	1463
File Format	PDF
ISSN	19390599
e-ISSN	19390599
Journal	Developmental psychology
Issue Number	5
Volume Number	48
Language	English
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Life-span and Life-course Studies Developmental and Educational Psychology Demography Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Demography Life-span and Life-course Studies Developmental and Educational Psychology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment

Interactions Between Serotonin Transporter Gene Haplotypes and Quality of Mothers’ Parenting Predict the Development of Children’s Noncompliance

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

Similarity in Depressive Symptoms in Adolescents’ Friendship Dyads: Selection or Socialization?

Trajectories of Emotional Well-Being in Mothers of Adolescents and Adults with Autism

A Developmental-Contextual Model of Depressive Symptoms in Mexican-Origin Female Adolescents

Patterns of Conflict Interaction in Mother–Toddler Dyads: Differences Between Depressed and Non-depressed Mothers

Accent, Perpetual Foreigner Stereotype, and Perceived Discrimination as Indirect Links between English Proficiency and Depressive Symptoms in Chinese American Adolescents

Trajectories of Individual Depressive Symptoms in Adolescents: Gender and Family Relationships as Predictors

Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents’ Trajectories of Anxious/Depressed Symptoms

Similar Documents

Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment

Interactions Between Serotonin Transporter Gene Haplotypes and Quality of Mothers’ Parenting Predict the Development of Children’s Noncompliance

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

Similarity in Depressive Symptoms in Adolescents’ Friendship Dyads: Selection or Socialization?

Trajectories of Emotional Well-Being in Mothers of Adolescents and Adults with Autism

A Developmental-Contextual Model of Depressive Symptoms in Mexican-Origin Female Adolescents

Patterns of Conflict Interaction in Mother–Toddler Dyads: Differences Between Depressed and Non-depressed Mothers

Accent, Perpetual Foreigner Stereotype, and Perceived Discrimination as Indirect Links between English Proficiency and Depressive Symptoms in Chinese American Adolescents

Trajectories of Individual Depressive Symptoms in Adolescents: Gender and Family Relationships as Predictors

Interaction Between Serotonin Transporter Polymorphism (5-HTTLPR) and Stressful Life Events in Adolescents’ Trajectories of Anxious/Depressed Symptoms