NDLI: Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

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Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

Content Provider	PubMed Central
Author	Palmieri, Giovannella Carlo, Buonerba Federico, Piera Formisano, Luigi Nappi, Lucia Lorenzo, Giuseppe Di Marino, Mirella Damiano, Vincenzo
Copyright Year	2012
Abstract	Although thymic epithelial tumors (TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic disease is invariably fatal. While several chemotherapy agents have proven to be effective in TETs, somatostatin analogs are the only targeted agents with an established role in this disease. Everolimus is an mTOR inhibitor with multiple application in oncology. In this report, we show for the first time that everolimus was effective in two heavily pretreated patients with advanced TETs, with a progression-free survival longer than 1 year and minimal toxicity.
Related Links	http://dx.doi.org/10.5306/wjco.v3.i7.111
Starting Page	111
File Format	PDF
ISSN	22184333
e-ISSN	22184333
Journal	World Journal of Clinical Oncology
Issue Number	7
Volume Number	3
Language	English
Publisher	Baishideng Publishing Group Co., Limited
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Co., Limited
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Oncology

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