NDLI: Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans

Content Provider	PubMed Central
Author	Antonio, Bascones-martÍnez Mercedes, LÓpez-durÁn Jorge, Cano-sÁnchez Lydia, SÁnchez-verde Ana, DÍez-rodrÍguez Pablo, Aguirre-echebarrÍa Álvarez-fernÁndez, Emilio Angel, GonzÁlez-moles Miguel Jaime, Bascones-ilundain Muzio, Lorenzo Lo Campo-trapero, JuliÁn
Copyright Year	2012
Abstract	Oncogene-induced senescence (OIS) may be a response to oncogenic activation, acting as a natural barrier against carcinogenesis at a premalignant stage. Thus, numerous cells in premalignant lesions enter senescence, but none or few in malignant tumours. This event could be due to the loss of senescence pathway effectors, including p16 (INK4a)-pRb or ARF-p53. The aim of this study was to characterize and compare the expression of certain senescent markers between oral precancer and cancer tissue samples. The expression of cyclin D1, Rb, maspin, p53 and mouse double minute 2 (MDM2) was analyzed in 20 paraffin-embedded tissue samples of normal oral mucosa (NOM), 14 samples of oral leukoplakia without dysplasia (OLD−), 11 samples of leukoplakia with dysplasia (OLD+) and 15 samples of oral squamous cell carcinoma (OSCC) by immunohistochemistry in tissue arrays. The expression of p16-pRb pathway markers, cyclin D1, maspin and Rb, was more frequent in OLD+ samples than in OSCC samples, although a statistical significance was only observed for maspin (P=0.036). Cyclin D1 expression was also significantly more frequent in OLD− samples vs. NOM samples. For the ARF-p53 pathway, the expression of p53 and MDM2 was significantly more frequent in the OLD− samples compared to in the NOM ones. These findings may indicate a role for cellular senescence in oral carcinogenesis, considering maspin as a reliable senescence marker and prognostic factor in oral premalignant lesions.
Related Links	http://dx.doi.org/10.3892/ol.2012.649
Starting Page	1319
File Format	PDF
ISSN	17921074
e-ISSN	17921082
Journal	Oncology Letters
Issue Number	6
Volume Number	3
Language	English
Publisher	D.A. Spandidos
Publisher Date	2012-03-01
Access Restriction	Open
Rights Holder	D.A. Spandidos
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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