NDLI: Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release

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Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release

Content Provider	PubMed Central
Author	Naga, Kranthi Kumari Geddes, James W.
Copyright Year	2010
Abstract	Dimebon was originally introduced as an antihistamine and subsequently investigated as a possible therapeutic for a variety of disorders, including Alzheimer's disease. One putative mechanism underlying the neuroprotective properties of Dimebon is inhibition of mitochondrial permeability transition, based on the observation that Dimebon inhibited the swelling of rat liver mitochondria induced by calcium and other agents that induce permeability transition. Because liver and brain mitochondria differ substantially in their properties and response to conditions associated with opening of the permeability transition pore, we sought to determine whether Dimebon inhibited permeability transition in brain mitochondria. Dimebon reduced calcium-induced mitochondrial swelling but did not enhance the calcium retention capacity or impair calcium-induced cytochrome C release from non-synaptic mitochondria isolated from rat brain cerebral cortex. These findings indicate that Dimebon does not inhibit mitochondrial permeability transition, induced by excessive calcium uptake, in brain mitochondria.
Related Links	http://dx.doi.org/10.1007/s12017-010-8130-x
Ending Page	36
Page Count	6
Starting Page	31
File Format	PDF
ISSN	15351084
e-ISSN	15591174
Journal	Neuromolecular Medicine
Issue Number	1
Volume Number	13
Language	English
Publisher Date	2011-03-01
Access Restriction	Open
Subject Keyword	Molecular Medicine Cellular and Molecular Neuroscience Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

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Dimebon Inhibits Calcium-Induced Swelling of Rat Brain Mitochondria But Does Not Alter Calcium Retention or Cytochrome C Release

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