NDLI: Rethinking dog domestication by integrating genetics, archeology, and biogeography

Content Provider	PubMed Central
Author	Larson, Greger Karlsson, Elinor K. Perri, Angela Webster, Matthew T. Ho, Simon Y. W. Peters, Joris Stahl, Peter W. Piper, Philip J. Lingaas, Frode Fredholm, Merete Comstock, Kenine E. Modiano, Jaime F. Schelling, Claude Agoulnik, Alexander I. Leegwater, Peter A. Dobney, Keith Vigne, Jean-denis Vilà, Carles Andersson, Leif Lindblad-toh, Kerstin
Abstract	The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called “ancient” breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog’s wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.
Related Links	http://dx.doi.org/10.1073/pnas.1203005109
Ending Page	8883
Page Count	6
Starting Page	8878
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-06-05
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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