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Pd and Mo Catalyzed Asymmetric Allylic Alkylation
| Content Provider | PubMed Central |
|---|---|
| Author | Trost, Barry M. |
| Abstract | The ability to control the alkylation of organic substrates becomes ever more powerful by using metal catalysts. Among the major benefits of metal catalysis is the possibility to perform such processes asymmetrically using only catalytic amounts of the chiral inducing agent which is a ligand to the metal of the catalyst. A unique aspect of asymmetric metal catalyzed processes is the fact that many mechanisms exist for stereoinduction. Furthermore, using the same catalyst system, many types of bonds including but not limited to C-C, C-N, C-O, C-S, C-P, and C-H can be formed asymmetrically. An overview of this process using palladium and molybdenum based metals being developed in my laboratories and how they influence strategy in synthesizing bioactive molecular targets is presented. |
| Related Links | http://dx.doi.org/10.1021/op200294r |
| Ending Page | 194 |
| Page Count | 10 |
| Starting Page | 185 |
| File Format | |
| ISSN | 10836160 |
| Journal | Organic process research & development |
| Issue Number | 2 |
| Volume Number | 16 |
| Language | English |
| Publisher Date | 2012-02-17 |
| Access Restriction | Open |
| Subject Keyword | Physical and Theoretical Chemistry Organic Chemistry Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Physical and Theoretical Chemistry |
