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Endothelial progenitor cells in atherosclerosis
| Content Provider | PubMed Central |
|---|---|
| Author | Du, Fuyong Zhou, Jun Gong, Ren Huang, Xiao Meghana, Pansuria Virtue, Anthony Li, Xinyuan Wang, Hong Yang, Xiao-feng |
| Abstract | Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial homoeostasis and in the process of new vessel formation. Experimental and clinical studies have shown that atherosclerosis is associated with reduced numbers and dysfunction of EPCs; and that medications alone are able to partially reverse the impairment of EPCs in patients with atherosclerosis. Therefore, novel EPC-based therapies may provide enhancement in restoring EPCs’ population and improvement of vascular function. Here, for a better understanding of the molecular mechanisms underlying EPC impairment in atherosclerosis, we provide a comprehensive overview on EPC characteristics, phenotypes, and the signaling pathways underlying EPC impairment in atherosclerosis. |
| Starting Page | 2327 |
| File Format | |
| ISSN | 10939946 |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Volume Number | 17 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |