NDLI: Immunocytochemical Colocalization of Fibroblast Growth Factor-1 with Neurotrophin-3 in Mouse Alveolar Macrophages

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Immunocytochemical Colocalization of Fibroblast Growth Factor-1 with Neurotrophin-3 in Mouse Alveolar Macrophages

Content Provider	PubMed Central
Author	Hiruma, Hiromi Hikawa, Shiori Kawakami, Tadashi
Copyright Year	2012
Abstract	Alveolar macrophages are known to express a variety of growth factors and neurotrophins. Fibroblast growth factor-1 (FGF-1) is abundantly present in the lung and has mitogenic and neurotrophic activities similarly to neurotrophins. In order to determine whether FGF-1 associates with neurotrophins in alveolar macrophages, we investigated the immunocytochemical colocalization of FGF-1 with neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), in mouse alveolar macrophages. The results showed that 34% of macrophages were immunoreactive for FGF-1, 10% for NGF, 9% for BDNF, and 17% for NT-3. Of FGF-1-immunoreactive (IR) macrophages, 16% were immunoreactive for NT-3, but only small percentages were immunoreactive for NGF (0.8%) and for BDNF (0.3%). FGF-1 and neurotrophins were all localized in the intracellular vesicles. In the vesicles, FGF-1 and NT-3 were frequently colocalized. All macrophages expressed lysosome-associated protein-2 (LAMP-2), a late endosomal and lysosomal marker, and early endosomes antigen 1 (EEA1), an early endosomal marker. FGF-1 and NT-3 were predominantly colocalized with LAMP-2 rather than with EEA1, whereas NGF and BDNF were colocalized with EEA1 rather than with LAMP-2. These results indicate that FGF-1 and NT-3 are substantially expressed in mouse alveolar macrophages and colocalized in vesicles, predominantly in late endosomes and lysosomes.
Related Links	http://dx.doi.org/10.1267/ahc.11055
Ending Page	137
Page Count	7
Starting Page	131
File Format	PDF
ISSN	00445991
e-ISSN	13475800
Journal	Acta Histochemica et Cytochemica
Issue Number	2
Volume Number	45
Language	English
Publisher	Japan Society of Histochemistry and Cytochemistry
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Japan Society of Histochemistry and Cytochemistry
Subject Keyword	Pathology and Forensic Medicine Cell Biology Biochemistry Physiology Histology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Histology Biochemistry Pathology and Forensic Medicine

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