NDLI: Social Cognition in Williams Syndrome: Genotype/Phenotype Insights from Partial Deletion Patients

Content Provider	PubMed Central
Author	Karmiloff-smith, Annette Broadbent, Hannah Farran, Emily K. Longhi, Elena D’souza, Dean Metcalfe, Kay May, Tassabehji Wu, Rachel Senju, Atsushi Happé, Francesca Peter, Turnpenny Sansbury, Francis
Copyright Year	2012
Abstract	Identifying genotype/phenotype relations in human social cognition has been enhanced by the study of Williams syndrome (WS). Indeed, individuals with WS present with a particularly strong social drive, and researchers have sought to link deleted genes in the WS critical region (WSCR) of chromosome 7q11.23 to this unusual social profile. In this paper, we provide details of two case studies of children with partial genetic deletions in the WSCR: an 11-year-old female with a deletion of 24 of the 28 WS genes, and a 14-year-old male who presents with the opposite profile, i.e., the deletion of only four genes at the telomeric end of the WSCR. We tested these two children on a large battery of standardized and experimental social perception and social cognition tasks – both implicit and explicit – as well as standardized social questionnaires and general psychometric measures. Our findings reveal a partial WS socio-cognitive profile in the female, contrasted with a more autistic-like profile in the male. We discuss the implications of these findings for genotype/phenotype relations, as well as the advantages and limitations of animal models and of case study approaches.
Related Links	http://dx.doi.org/10.3389/fpsyg.2012.00168
Starting Page	168
File Format	PDF
ISSN	16641078
e-ISSN	16641078
Journal	Frontiers in Psychology
Volume Number	3
Language	English
Publisher	Frontiers Research Foundation
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Frontiers Research Foundation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Psychology

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