NDLI: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Content Provider	PubMed Central
Author	Nader, Joëlle Claudia, Chauvet Rawas, Rana El Laure, Favot Jaber, Mohamed Thiriet, Nathalie Solinas, Marcello
Copyright Year	2012
Abstract	Life experiences, especially during critical periods of maturation, such as adolescence, can dramatically affect vulnerability to diseases at adulthood. Early exposure to positive environmental conditions such as environmental enrichment (EE) has been shown to reduce the occurrence and the intensity of neurological and psychiatric disorders including drug addiction. However, whether or not exposure to EE during early stages of life would protect from addiction when, at adulthood, individuals may find themselves in non-enriched conditions has not been investigated. Here we show that switching mice from EE to non-enriched standard environments not only results in the loss of the preventive effects of EE but also increases the rewarding effects of cocaine. This enhanced vulnerability is associated with emotional distress and with increased levels in the mRNA levels of corticotropin releasing factor (CRF) in the bed nucleus of the stria terminalis (BNST), as well as with increases in CREB phosphorylation in the BNST and in the shell of the nucleus accumbens. The increased sensitivity to the rewarding effects of cocaine is completely blocked by the CRF antagonist antalarmin, confirming a major role of the CRF system in the negative consequences of this environmental switch. These results indicate that positive life conditions during early stages of life, if they are not maintained at adulthood, may have negative emotional consequences and increase the risks to develop drug addiction.
Related Links	http://dx.doi.org/10.1038/npp.2012.2
Ending Page	1587
Page Count	9
Starting Page	1579
File Format	PDF
ISSN	0893133X
e-ISSN	1740634X
Journal	Neuropsychopharmacology
Issue Number	7
Volume Number	37
Language	English
Publisher	Nature Publishing Group
Publisher Date	2012-06-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Erratum: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Erratum: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

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The Neuropsychology of Cocaine Addiction: Recent Cocaine Use Masks Impairment

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Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

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Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

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