NDLI: Immature integration and segregation of emotion-related brain circuitry in young children

Content Provider	PubMed Central
Author	Qin, Shaozheng Young, Christina B. Supekar, Kaustubh Uddin, Lucina Q. Menon, Vinod
Abstract	The human brain undergoes protracted development, with dramatic changes in expression and regulation of emotion from childhood to adulthood. The amygdala is a brain structure that plays a pivotal role in emotion-related functions. Investigating developmental characteristics of the amygdala and associated functional circuits in children is important for understanding how emotion processing matures in the developing brain. The basolateral amygdala (BLA) and centromedial amygdala (CMA) are two major amygdalar nuclei that contribute to distinct functions via their unique pattern of interactions with cortical and subcortical regions. Almost nothing is currently known about the maturation of functional circuits associated with these amygdala nuclei in the developing brain. Using intrinsic connectivity analysis of functional magnetic resonance imaging data, we investigated developmental changes in functional connectivity of the BLA and CMA in twenty-four 7- to 9-y-old typically developing children compared with twenty-four 19- to 22-y-old healthy adults. Children showed significantly weaker intrinsic functional connectivity of the amygdala with subcortical, paralimbic, and limbic structures, polymodal association, and ventromedial prefrontal cortex. Importantly, target networks associated with the BLA and CMA exhibited greater overlap and weaker dissociation in children. In line with this finding, children showed greater intraamygdala connectivity between the BLA and CMA. Critically, these developmental differences were reproducibly identified in a second independent cohort of adults and children. Taken together, our findings point toward weak integration and segregation of amygdala circuits in young children. These immature patterns of amygdala connectivity have important implications for understanding typical and atypical development of emotion-related brain circuitry.
Related Links	http://dx.doi.org/10.1073/pnas.1120408109
Ending Page	7946
Page Count	6
Starting Page	7941
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-05-15
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Immature integration and segregation of emotion-related brain circuitry in young children.

Persistence and brain circuitry

Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation

Visualization of functionally activated circuitry in the brain

Large-scale, heterogeneous integration of nanowire arrays for image sensor circuitry

Development of distinct control networks through segregation and integration

Aneuploid neurons are functionally active and integrated into brain circuitry

A measure for brain complexity: relating functional segregation and integration in the nervous system.

Underconnectivity between voice-selective cortex and reward circuitry in children with autism

Immature integration and segregation of emotion-related brain circuitry in young children

Similar Documents

Immature integration and segregation of emotion-related brain circuitry in young children.

Persistence and brain circuitry

Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation

Visualization of functionally activated circuitry in the brain

Large-scale, heterogeneous integration of nanowire arrays for image sensor circuitry

Development of distinct control networks through segregation and integration

Aneuploid neurons are functionally active and integrated into brain circuitry

A measure for brain complexity: relating functional segregation and integration in the nervous system.

Underconnectivity between voice-selective cortex and reward circuitry in children with autism

Immature integration and segregation of emotion-related brain circuitry in young children