NDLI: Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection

Content Provider	PubMed Central
Author	Chen, Chen-yu Chang, Chia-chen Yu, Chun Lin, Chii-wann
Copyright Year	2012
Abstract	Preterm birth is the leading cause of perinatal morbidity and mortality. Fetal fibronectin (fFN), a glycoprotein in the extracellular matrix of the amniotic membranes, is the most powerful biomarker for predicting the risk of preterm birth. Biosensors using the surface plasmon resonance (SPR) response are potentially useful in quantitatively measuring molecules. We established a standard calibration curve of SPR intensity against fFN concentration and used the SPR-based biosensor to detect fFN concentrations in the cervicovaginal secretions of pregnant women between 22 and 34 weeks of gestation. The calibration curve extends from 0.5 ng/mL to 100 ng/mL with an excellent correlation (R2 = 0.985) based on standard fFN samples. A cutoff value of 50 ng/mL fFN concentration in commercial ELISA kits corresponds to a relative intensity of 17 arbitrary units (a.u.) in SPR. Thirty-two pregnant women were analyzed in our study. In 11 women, the SPR relative intensity was greater than or equal to 17 a.u., and in 21 women, the SPR relative intensity was less than 17 a.u. There were significant differences between the two groups in regular uterine contractions (p = 0.040), hospitalization for tocolysis (p = 0.049), and delivery weeks (p = 0.043). Our prospective study concluded that SPR-based biosensors can quantitatively measure fFN concentrations. These results reveal the potential utility of SPR-based biosensors in predicting the risk of preterm birth.
Related Links	http://dx.doi.org/10.3390/s120403879
Ending Page	3890
Page Count	12
Starting Page	3879
File Format	PDF
ISSN	14248220
e-ISSN	14248220
Journal	Sensors (Basel, Switzerland)
Issue Number	4
Volume Number	12
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2012-03-01
Access Restriction	Open
Rights Holder	Molecular Diversity Preservation International (MDPI)
Subject Keyword	Electrical and Electronic Engineering Analytical Chemistry Atomic and Molecular Physics, and Optics Biochemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Atomic and Molecular Physics, and Optics Instrumentation Analytical Chemistry Biochemistry Information Systems Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Fiber Surface Modification Technology for Fiber-Optic Localized Surface Plasmon Resonance Biosensors

Surface Plasmon Resonance for Cell-Based Clinical Diagnosis

Glycopeptide-Based Antibody Detection in Multiple Sclerosis by Surface Plasmon Resonance

Toxin Detection by Surface Plasmon Resonance

Surface Plasmon Resonance Based Biosensors for Exploring the Influence of Alkaloids on Aggregation of Amyloid-β Peptide

Development of Phase Detection Schemes Based on Surface Plasmon Resonance Using Interferometry

Surface Plasmon Resonance Based Temperature Sensors in Liquid Environment

Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection

Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor

Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection

Similar Documents

Fiber Surface Modification Technology for Fiber-Optic Localized Surface Plasmon Resonance Biosensors

Surface Plasmon Resonance for Cell-Based Clinical Diagnosis

Glycopeptide-Based Antibody Detection in Multiple Sclerosis by Surface Plasmon Resonance

Toxin Detection by Surface Plasmon Resonance

Surface Plasmon Resonance Based Biosensors for Exploring the Influence of Alkaloids on Aggregation of Amyloid-β Peptide

Development of Phase Detection Schemes Based on Surface Plasmon Resonance Using Interferometry

Surface Plasmon Resonance Based Temperature Sensors in Liquid Environment

Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection

Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor

Clinical Application of Surface Plasmon Resonance-Based Biosensors for Fetal Fibronectin Detection