NDLI: Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging

Content Provider	PubMed Central
Author	Shulman, Robert G. Hyder, Fahmeed Rothman, Douglas L.
Copyright Year	2001
Abstract	Positron-emission tomography and functional MRS imaging signals can be analyzed to derive neurophysiological values of cerebral blood flow or volume and cerebral metabolic consumption rates of glucose (CMRGlc) or oxygen (CMRO2 ). Under basal physiological conditions in the adult mammalian brain, glucose oxidation is nearly complete so that the oxygen-to-glucose index (OGI), given by the ratio of CMRO2 /CMRGlc, is close to the stoichiometric value of 6. However, a survey of functional imaging data suggests that the OGI is activity dependent, moving further below the oxidative value of 6 as activity is increased. Brain lactate concentrations also increase with stimulation. These results had led to the concept that brain activation is supported by anaerobic glucose metabolism, which was inconsistent with basal glucose oxidation. These differences are resolved here by a proposed model of glucose energetics, in which a fraction of glucose is cycled through the cerebral glycogen pool, a fraction that increases with degree of brain activation. The “glycogen shunt,” although energetically less efficient than glycolysis, is followed because of its ability to supply glial energy in milliseconds for rapid neurotransmitter clearance, as a consequence of which OGI is lowered and lactate is increased. The value of OGI observed is consistent with passive lactate efflux, driven by the observed lactate concentration, for the few experiments with complete data. Although the OGI changes during activation, the energies required per neurotransmitter release (neuronal) and clearance (glial) are constant over a wide range of brain activity.
Related Links	http://dx.doi.org/10.1073/pnas.101129298
Starting Page	6417
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	98
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2001-05-22
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging.

The “glycogen shunt” in exercising muscle: A role for glycogen in muscle energetics and fatigue

Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI

The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue.

Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast

In Vivo Neurochemical Profiling of Rat Brain by 1H-[13C] NMR Spectroscopy. Cerebral Energetics and Glutamatergic/GABAergic Neurotransmission

Structural basis for the recruitment of glycogen synthase by glycogenin

The 'glycogen shunt' in exercising muscle: A role for glycogen in muscle energetics and fatigue.

Neurochemical basis for the photic control of circadian rhythms and seasonal reproductive cycles: role for acetylcholine.

Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging

Similar Documents

Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging.

The “glycogen shunt” in exercising muscle: A role for glycogen in muscle energetics and fatigue

Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI

The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue.

Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast

In Vivo Neurochemical Profiling of Rat Brain by 1H-[13C] NMR Spectroscopy. Cerebral Energetics and Glutamatergic/GABAergic Neurotransmission

Structural basis for the recruitment of glycogen synthase by glycogenin

The 'glycogen shunt' in exercising muscle: A role for glycogen in muscle energetics and fatigue.

Neurochemical basis for the photic control of circadian rhythms and seasonal reproductive cycles: role for acetylcholine.

Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging