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| Content Provider | PubMed Central |
|---|---|
| Author | Yin, Na Xu, Jiangnan Florent, Ginhoux Randolph, Gwendalyn J. Merad, Miriam Ding, Yaozhong Bromberg, Jonathan S. |
| Abstract | Dendritic cells (DC) play important roles in both tolerance and immunity to β-cells in type 1 diabetes. How and why DC can have diverse and opposing functions in islets remains elusive. To answer these questions, islet DC subsets and their specialized functions were characterized. Under both homeostatic and inflammatory conditions, there were two main tissue resident DC subsets in islets, defined as CD11blo/−CD103+CX3CR1− (CD103+DC), the majority of which were derived from Flt3 dependent pre-DC; and CD11b+CD103−CX3CR1+ (CD11b+DC), the majority of which were derived from monocytes. CD103+DC were the major migratory DC and cross-presented islet derived antigen in the pancreatic draining lymph node (LN), although this DC subset displayed limited phagocytic activity. CD11b+DC were numerically the predominant subset (60–80%), but poorly migrated to the draining LN. Although CD11b+ DC had greater phagocytic activity, they poorly presented antigen to T cells. CD11b+DC increased in numbers and percentage during T cell mediated insulitis, suggesting that this subset might be involved in the pathogenesis of diabetes. These data elucidate the phenotype and function of homeostatic and inflammatory islet DC, suggesting differential roles in islet immunity. |
| Related Links | http://dx.doi.org/10.4049/jimmunol.1103725 |
| Ending Page | 4930 |
| Page Count | 10 |
| Starting Page | 4921 |
| File Format | |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| Journal | Journal of Immunology (Baltimore, Md. : 1950) |
| Issue Number | 10 |
| Volume Number | 188 |
| Language | English |
| Publisher Date | 2012-05-15 |
| Access Restriction | Open |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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