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Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

Content Provider	PubMed Central
Author	Young, J’nelle S. Vogl, A. Wayne
Copyright Year	2012
Abstract	Tubulobulbar complexes (TBCs) are actin-related double-membrane invaginations formed at intercellular junctions in the seminiferous epithelium of mammalian testis. They occur at basal junction complexes between neighboring Sertoli cells and at apical junctions between Sertoli cells and spermatids. They are proposed to internalize intercellular junctions during the translocation of spermatocytes from basal to adluminal compartments of the seminiferous epithelium, and during sperm release from Sertoli cells. Although TBCs are specific to the seminiferous epithelium, they morphologically resemble podosomes in osteoclasts. Previously, we have reported that a key group of proteins consisting of N-WASp, Arp2/3, cortactin and dynamin that occur at podosomes also is present at TBCs. Here we explore the prediction that zyxin, a focal adhesion protein known to be present at podosomes, also is present at apical TBCs. A rabbit polyclonal anti-zyxin antibody (B71) was used to label fixed fragments and frozen sections of testis. In both fragments and sections, B71 labeled tubular regions of TBCs at apical sites of attachment between Sertoli cells and spermatids, in addition to being localized at actin related intercellular adhesion junctions termed ectoplasmic specializations. Although the function of zyxin at TBCs has yet to be determined, the protein is known to interact with the cytoplasmic domain of integrins at focal adhesions, and integrins are known to be present in TBCs.
Related Links	http://dx.doi.org/10.4161/spmg.19391
Ending Page	68
Page Count	6
Starting Page	63
File Format	PDF
ISSN	21565562
e-ISSN	21565562
Journal	Spermatogenesis
Issue Number	1
Volume Number	2
Language	English
Publisher	Landes Bioscience
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Spermatogenesis Research in Higher Education
Content Type	Text
Resource Type	Article

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Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

REPORT Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes (2012)

Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation.

Zyxin and vinculin distribution at the Cell-extracellular Matrix Attachment Complex (CMAX) in corneal epithelial tissue are actin dependent

VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module

Zyxin‐involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status

Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions (2001)

Zyxin and Vinculin Distribution at the Cell-Extracellular Matrix Attachment Complex (CMAX) in Corneal Epithelial Tissue are Actin Dependent

Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

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Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

REPORT Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes (2012)

Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes

Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation.

Zyxin and vinculin distribution at the Cell-extracellular Matrix Attachment Complex (CMAX) in corneal epithelial tissue are actin dependent

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Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes