NDLI: Social environment is associated with gene regulatory variation in the rhesus macaque immune system

Content Provider	PubMed Central
Author	Tung, Jenny Barreiro, Luis B. Johnson, Zachary P. Hansen, Kasper D. Michopoulos, Vasiliki Toufexis, Donna Michelini, Katelyn Wilson, Mark E. Gilad, Yoav
Abstract	Variation in the social environment is a fundamental component of many vertebrate societies. In humans and other primates, adverse social environments often translate into lasting physiological costs. The biological mechanisms associated with these effects are therefore of great interest, both for understanding the evolutionary impacts of social behavior and in the context of human health. However, large gaps remain in our understanding of the mechanisms that mediate these effects at the molecular level. Here we addressed these questions by leveraging the power of an experimental system that consisted of 10 social groups of female macaques, in which each individual's social status (i.e., dominance rank) could be experimentally controlled. Using this paradigm, we show that dominance rank results in a widespread, yet plastic, imprint on gene regulation, such that peripheral blood mononuclear cell gene expression data alone predict social status with 80% accuracy. We investigated the mechanistic basis of these effects using cell type-specific gene expression profiling and glucocorticoid resistance assays, which together contributed to rank effects on gene expression levels for 694 (70%) of the 987 rank-related genes. We also explored the possible contribution of DNA methylation levels to these effects, and identified global associations between dominance rank and methylation profiles that suggest epigenetic flexibility in response to status-related behavioral cues. Together, these results illuminate the importance of the molecular response to social conditions, particularly in the immune system, and demonstrate a key role for gene regulation in linking the social environment to individual physiology.
Related Links	http://dx.doi.org/10.1073/pnas.1202734109
Ending Page	6495
Page Count	6
Starting Page	6490
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-04-24
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Social environment is associated with gene regulatory variation in the rhesus macaque immune system.

Oxytocin blunts social vigilance in the rhesus macaque

Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

Variation in the X-Linked EFHC2 Gene Is Associated with Social Cognitive Abilities in Males

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills

Viral Interferon Regulatory Factors Are Critical for Delay of the Host Immune Response against Rhesus Macaque Rhadinovirus Infection

Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque

Rhesus Macaque Rhadinovirus-Associated Disease

Social environment is associated with gene regulatory variation in the rhesus macaque immune system

Similar Documents

Social environment is associated with gene regulatory variation in the rhesus macaque immune system.

Oxytocin blunts social vigilance in the rhesus macaque

Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

Variation in the X-Linked EFHC2 Gene Is Associated with Social Cognitive Abilities in Males

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills

Viral Interferon Regulatory Factors Are Critical for Delay of the Host Immune Response against Rhesus Macaque Rhadinovirus Infection

Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque

Rhesus Macaque Rhadinovirus-Associated Disease

Social environment is associated with gene regulatory variation in the rhesus macaque immune system