NDLI: Rapid Thymic Reconstitution Following Bone Marrow Transplantation in Neonatal Mice is VEGF-Dependent

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Rapid Thymic Reconstitution Following Bone Marrow Transplantation in Neonatal Mice is VEGF-Dependent

Content Provider	PubMed Central
Author	Cuddihy, Andrew R. Suterwala, Batul T. Ge, Shundi Kohn, Lisa A. Jang, Julie Andrade, Jacob Wang, Xiaoyan Crooks, Gay M.
Copyright Year	2012
Abstract	Age-related differences in thymic function influence the rapidity of T cell reconstitution following hematopoietic stem cell transplantation (HSCT). In adults, thymic reconstitution is delayed until after marrow engraftment is established, and is significantly improved by approaches that increase marrow chimerism, such as pre-transplant irradiation. In contrast, we show that neonatal mice undergo more rapid and efficient thymic reconstitution than adults, even when bone marrow engraftment is minimal and in the absence of pre-transplant radiation. We have previously shown that the neonatal thymus produces high levels of vascular endothelial growth factor (VEGF) that drives angiogenesis locally. In this report we show that inhibition of VEGF prior to HSCT prevents rapid thymic reconstitution in neonates, but has no effect on thymic reconstitution in adults. These data suggest that the early, radiation independent, thymic reconstitution unique to the neonatal host is mediated through VEGF, and reveals a novel pathway that might be targeted to improve immune reconstitution post-HSCT.
Related Links	http://dx.doi.org/10.1016/j.bbmt.2012.01.006
Ending Page	689
Page Count	7
Starting Page	683
File Format	PDF
ISSN	10838791
e-ISSN	15236536
Journal	Biology of Blood and Marrow Transplantation
Issue Number	5
Volume Number	18
Language	English
Publisher Date	2012-05-01
Access Restriction	Open
Subject Keyword	Transplantation Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Hematology Transplantation

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