NDLI: Invasion of eukaryotic cells by Legionella pneumophila: A common strategy for all hosts?

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Invasion of eukaryotic cells by Legionella pneumophila: A common strategy for all hosts?

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Invasion of eukaryotic cells by Legionella pneumophila: A common strategy for all hosts?

Content Provider	PubMed Central
Author	Hoffman, Paul S.
Copyright Year	1997
Abstract	Legionella pneumophila is an environmental micro-organism capable of producing an acute lobar pneumonia, commonly referred to as Legionnaires’ disease, in susceptible humans. Legionellae are ubiquitous in aquatic environments, where they survive in biofilms or intracellularly in various protozoans. Susceptible humans become infected by breathing aerosols laden with the bacteria. The target cell for human infection is the alveolar macrophage, in which the bacteria abrogate phagolysosomal fusion. The remarkable ability of L pneumophila to infect a wide range of eukaryotic cells suggests a common strategy that exploits very fundamental cellular processes. The bacteria enter host cells via coiling phagocytosis and quickly subvert organelle trafficking events, leading to formation of a replicative phagosome in which the bacteria multiply. Vegetative growth continues for 8 to 10 h, after which the bacteria develop into a short, highly motile form called the ‘mature form’. The mature form exhibits a thickening of the cell wall, stains red with the Gimenez stain, and is between 10 and 100 times more infectious than agar-grown bacteria. Following host cell lysis, the released bacteria infect other host cells, in which the mature form differentiates into a Gimenez-negative vegetative form, and the cycle begins anew. Virulence of L pneumophila is considered to be multifactorial, and there is growing evidence for both stage specific and sequential gene expression. Thus, L pneumophila may be a good model system for dissecting events associated with the host-parasite interactions.
Starting Page	139
File Format	PDF
ISSN	11802332
Journal	The Canadian Journal of Infectious Diseases
Issue Number	3
Volume Number	8
Language	English
Publisher	Pulsus Group Inc
Publisher Date	1997-01-01
Access Restriction	Open
Rights Holder	Pulsus Group Inc
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical)

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