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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Zhen-bo Ou, Xiang-hong Tong, Jing-shan Li, Sen Wei, Liang Ouyang, Ying-chun Hou, Yi Schatten, Heide Sun, Qing-yuan |
| Copyright Year | 2010 |
| Abstract | Sumoylation is an important posttranslational modification in which SUMO (small ubiquitin-related modifier) proteins are bonded covalently to their substrates. Studies on the roles of sumoylation in cell cycle regulation have been emerging in both mitosis from yeast to mammals and meiosis in budding yeast, but the functions of sumoylation in mammalian meiosis, especially in oocyte meiotic maturation are not well known. Here, we examined the localization and expression of SUMO-1 and SUMO-2/3, the two basic proteins in the sumoylation pathway and investigated their roles through overexpression of Senp2 during mouse oocyte maturation. Immunofluorescent staining revealed differential patterns of SUMO-1 and SUMO-2/3 localization: SUMO-1 was localized to the spindle poles in prometaphase I, MI and MII stages, around the separating homologues in anaphase I and telophase I stages of first meiosis, while SUMO-2/3 was mainly concentrated near centromeres during mouse oocyte maturation. Immunoblot analysis uncovered the different expression profiles of SUMO-1 and SUMO-2/3 modified proteins during mouse oocyte maturation. Overexpression of Senp2, a SUMO-specific isopeptidase, caused changes of SUMO-modified proteins and led to defects in MII spindle organization in mature eggs. These results suggest that the SUMO pathway may play an indispensable role during mouse oocyte meiotic maturation. |
| Related Links | http://dx.doi.org/10.4161/cc.9.13.12120 |
| Ending Page | 2646 |
| Page Count | 7 |
| Starting Page | 2640 |
| File Format | |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| Journal | Cell Cycle |
| Issue Number | 13 |
| Volume Number | 9 |
| Language | English |
| Publisher | Landes Bioscience |
| Publisher Date | 2010-07-01 |
| Access Restriction | Open |
| Rights Holder | Landes Bioscience |
| Subject Keyword | Developmental Biology Cell Biology Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
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