NDLI: HIV-1 Vif promotes the G1- to S-phase cell-cycle transition

Content Provider	PubMed Central
Author	Wang, Jiangfang Reuschel, Emma L. Shackelford, Jason M. Lauren, Jeang Shivers, Debra K. Diehl, J. Alan Yu, Xiao-fang Finkel, Terri H.
Copyright Year	2011
Abstract	HIV-1 depends on host-cell resources for replication, access to which may be limited to a particular phase of the cell cycle. The HIV-encoded proteins Vpr (viral protein R) and Vif (viral infectivity factor) arrest cells in the G2 phase; however, alteration of other cell-cycle phases has not been reported. We show that Vif drives cells out of G1 and into the S phase. The effect of Vif on the G1-to-S transition is distinct from its effect on G2, because G2 arrest is Cullin5-dependent, whereas the G1-to-S progression is Cullin5-independent. Using mass spectrometry, we identified 2 novel cellular partners of Vif, Brd4 and Cdk9, both of which are known to regulate cell-cycle progression. We confirmed the interaction of Vif and Cdk9 by immunoprecipitation and Western blot, and showed that small interfering RNAs (siRNAs) specific for Cdk9 inhibit the Vif-mediated G1-to-S transition. These data suggest that Vif regulates early cell-cycle progression, with implications for infection and latency.
Related Links	http://dx.doi.org/10.1182/blood-2010-06-289215
Ending Page	1269
Page Count	10
Starting Page	1260
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	4
Volume Number	117
Language	English
Publisher	American Society of Hematology
Publisher Date	2011-01-27
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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