NDLI: CD4+CD25+ Regulatory T Cell Ontogeny and Preferential Migration to the Cecal Tonsils in Chickens

Content Provider	PubMed Central
Author	Shanmugasundaram, Revathi Selvaraj, Ramesh K.
Editor	Frey, Oliver
Copyright Year	2012
Abstract	Thymic CD4+CD25+ cells have regulatory-T-cell-like properties in chickens. This study examined the ontogeny of CD4+CD25+ cells in the thymus and in peripheral compartments in chickens. CD4+CD25+ cells started to appear in the thymus at day 15 of incubation (E15), although at low percentages. Expressed as a percentage of CD4+ cells, CD4+CD25+ cells increased (P<0.01) from 1.7% at E20 to 7.3% at 0 d post-hatch (D0). CD4+CD25+ cells did not appear in the spleen or cecal tonsils of embryos. Expressed as a percentage of CD4+ cells, CD4+CD25+ cells increased (P<0.01) from 0% at D0 to 27% at D1 in cecal tonsils and from 0% at D0 to 11% at D1 in the spleen. Expressed as a percentage of all mononuclear cells, cecal tonsils at D1 had approximately 3.5-fold higher percentage of CD4+CD25+ cells than the spleen at D1. CD4+CD25+ cells from cecal tonsils of chicks at D1 were suppressive. CD4+CD25+ cells from D0 thymus, when injected back into MHC-compatible chicks, migrated to cecal tonsils and lungs and were detected until 10 d post-injection. CD4+CD25+ cells from cecal tonsils had a higher (P = 0.01) relative amount of CCR9 mRNA than CD4+CD25+ cells from the thymus. It could be concluded that in chickens CD4+CD25+ cells migrate from the thymus immediately post-hatch and preferentially colonize the gut associated lymphoid tissues. CD4+CD25+ cells' preferential migration to cecal tonsils is likely directed through the CCR9 pathway in chickens.
Related Links	http://dx.doi.org/10.1371/journal.pone.0033970
Starting Page	33970
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	3
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-03-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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