NDLI: Location, location, location: the BRMS1 protein and melanoma progression

Content Provider	PubMed Central
Author	Samant, Rajeev S. Riker, Adam I.
Copyright Year	2012
Abstract	The metastasis suppressor, BRMS1, has been demonstrated to cause dramatic regression of metastatic lesions without blocking orthotopic tumor growth. The role of BRMS1 is well-documented for several non-melanoma malignancies, such as breast cancer, ovarian cancer and non-small-cell lung cancer. However, its role in melanoma is just beginning to be understood, with a recent article by Slipicevic et al. highlighting the levels of expression of BRMS1 in benign nevi, primary and metastatic melanoma samples. Their findings emphasize that the intracellular location of BRMS1 protein (cytoplasmic or nuclear), appears to have a significant impact upon the metastatic capacity of melanoma cells. Interestingly, this selective localization translates into a statistically significant decrease in the relapse-free period in melanoma patients, further associated with a thicker Breslow's depth of primary melanomas. However, and more importantly, this study begins to define a clearer role for BRMS1 in melanoma that is strictly dependent upon its cellular location, with nuclear expression associated with invasive and metastatic capacity and cytoplasmic expression resulting in repressive effects upon progression and metastasis.
Related Links	http://dx.doi.org/10.1186/preaccept-2032291833666638
Starting Page	19
File Format	PDF
ISSN	17417015
e-ISSN	17417015
Journal	BMC Medicine
Volume Number	10
Language	English
Publisher	BioMed Central
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Location, location, location: the BRMS1 protein and melanoma progression

Location, location, location: the BRMS1 protein and melanoma progression

Location, location, location: regulation of breast cancer progression by the microenvironment

BRMS1 Suppresses Glioma Progression by Regulating Invasion, Migration and Adhesion of Glioma Cells

Expression of the metastasis suppressor BRMS1 in uveal melanoma

Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion

Treatment and Outcomes of Melanoma in Acral Location in Korean Patients

The relationship between blood IL-12p40 level and melanoma progression

Insulin-Like-Growth-Factor-Binding-Protein-3 (IGFBP-3) Contrasts Melanoma Progression In Vitro and In Vivo

Location, location, location: the BRMS1 protein and melanoma progression

Similar Documents

Location, location, location: the BRMS1 protein and melanoma progression

Location, location, location: the BRMS1 protein and melanoma progression

Location, location, location: regulation of breast cancer progression by the microenvironment

BRMS1 Suppresses Glioma Progression by Regulating Invasion, Migration and Adhesion of Glioma Cells

Expression of the metastasis suppressor BRMS1 in uveal melanoma

Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion

Treatment and Outcomes of Melanoma in Acral Location in Korean Patients

The relationship between blood IL-12p40 level and melanoma progression

Insulin-Like-Growth-Factor-Binding-Protein-3 (IGFBP-3) Contrasts Melanoma Progression In Vitro and In Vivo

Location, location, location: the BRMS1 protein and melanoma progression