NDLI: Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons

Content Provider	PubMed Central
Author	Baranek, Constanze Dittrich, Manuela Parthasarathy, Srinivas Gaiser, Bonnon Carine Olga, Britanova Lanshakov, Dmitriy Fatiha, Boukhtouche Sommer, Julia E. Colmenares, Clemencia Victor, Tarabykin Atanasoski, Suzana
Abstract	First insights into the molecular programs orchestrating the progression from neural stem cells to cortical projection neurons are emerging. Loss of the transcriptional regulator Ski has been linked to the human 1p36 deletion syndrome, which includes central nervous system defects. Here, we report critical roles for Ski in the maintenance of the neural stem cell pool and the specification of callosal neurons. Ski-deficient callosal neurons lose their identity and ectopically express the transcription factor Ctip2. The misspecified callosal neurons largely fail to form the corpus callosum and instead redirect their axons toward subcortical targets. We identify the chromatin-remodeling factor Satb2 as a partner of Ski, and show that both proteins are required for transcriptional repression of Ctip2 in callosal neurons. We propose a model in which Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex. Our findings establish a central role for Ski–Satb2 interactions in regulating transcriptional mechanisms of callosal neuron specification.
Related Links	http://dx.doi.org/10.1073/pnas.1108718109
Ending Page	3551
Page Count	6
Starting Page	3546
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-02-28
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

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Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons