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| Content Provider | PubMed Central |
|---|---|
| Author | Cavo, Michele Rajkumar, S. Vincent Palumbo, Antonio Moreau, Philippe Orlowski, Robert Joan, Bladé Sezer, Orhan Ludwig, Heinz Dimopoulos, Meletios A. Attal, Michel Sonneveld, Pieter Mario, Boccadoro Anderson, Kenneth C. Richardson, Paul G. Bensinger, William Johnsen, Hans E. Kroeger, Nicolaus Gahrton, Gösta Leif, Bergsagel P. Vesole, David H. Hermann, Einsele Jagannath, Sundar Ruben, Niesvizky Durie, Brian G. M. Miguel, Jesus San Sagar, Lonial |
| Copyright Year | 2011 |
| Abstract | The role of high-dose therapy followed by autologous stem cell transplantation (ASCT) in the treatment of multiple myeloma (MM) continues to evolve in the novel agent era. The choice of induction therapy has moved from conventional chemotherapy to newer regimens incorporating the immunomodulatory derivatives thalidomide or lenalidomide and the proteasome inhibitor bortezomib. These drugs combine well with traditional therapies and with one another to form various doublet, triplet, and quadruplet regimens. Up-front use of these induction treatments, in particular 3-drug combinations, has affected unprecedented rates of complete response that rival those previously seen with conventional chemotherapy and subsequent ASCT. Autotransplantation applied after novel-agent-based induction regimens provides further improvement in the depth of response, a gain that translates into extended progression-free survival and, potentially, overall survival. High activity shown by immunomodulatory derivatives and bortezomib before ASCT has recently led to their use as consolidation and maintenance therapies after autotransplantation. Novel agents and ASCT are complementary treatment strategies for MM. This article reviews the current literature and provides important perspectives and guidance on the major issues surrounding the optimal current management of younger, transplantation-eligible MM patients. |
| Related Links | http://dx.doi.org/10.1182/blood-2011-02-297325 |
| Starting Page | 6063 |
| File Format | |
| ISSN | 15280020 |
| e-ISSN | 15280020 |
| Journal | Blood |
| Issue Number | 23 |
| Volume Number | 117 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2011-06-09 |
| Access Restriction | Open |
| Rights Holder | American Society of Hematology |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Hematology Biochemistry Immunology |
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